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Glucoraphanin: A broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance
https://doi.org/10.24517/00051317
https://doi.org/10.24517/000513179a46fb06-716c-4934-ac48-803fb2635fb1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAGATA-N-218.pdf (663.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-10-26 | |||||||||
| タイトル | ||||||||||
| タイトル | Glucoraphanin: A broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00051317 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Xu, Liang
× Xu, Liang× Nagata, Naoto× Ota, Tsuguhito |
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| 著者別表示 |
長田, 直人
× 長田, 直人
× 太田, 嗣人
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Adipocyte 巻 7, 号 3, p. 218-225, 発行日 2018-08-09 |
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| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1080/21623945.2018.1474669 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Taylor & Francis | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD). Particularly, obesity-induced metabolic endotoxemia plays an important role in the pathogenesis of insulin resistance and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of antioxidant signaling that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Pharmacological stimulation of Nrf2 mitigates obesity and insulin resistance in mice; however, Nrf2 activators are not clinically available due to biosafety concerns. A recent study demonstrated that glucoraphanin, a precursor of the Nrf2 activator sulforaphane, ameliorates obesity by enhancing energy expenditure and browning of white adipose tissue, and attenuates obesity-related inflammation and insulin resistance by polarizing M2 macrophages and reducing metabolic endotoxemia. Thus, this review focuses on the efficiency and safety of glucoraphanin in alleviating obesity, insulin resistance, and NAFLD. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Embargo Period 12 months | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright © Taylor & Francis | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1474669 | |||||||||
| 関連名称 | https://www.tandfonline.com/doi/full/10.1080/21623945.2018.1474669 | |||||||||
