{"created":"2023-07-27T06:51:34.811762+00:00","id":45057,"links":{},"metadata":{"_buckets":{"deposit":"6d2e9eb7-dbbf-46f0-bf9b-0f8189cb2919"},"_deposit":{"created_by":18,"id":"45057","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45057"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045057","sets":["2812:2813:2816"]},"author_link":["78403","78404"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"造血細胞移植により難治性の血液疾患が治療できるようになって久しい。しかしながらドナーから供給された骨髄細胞による負の側面、いわゆる移植片対宿主病 (GVHD) は克服されていない。我々は、慢性GVHDに対して、マウス骨髄移植モデルと用いて新規治療の開拓を目指してきた。本研究は、慢性GVHD発症の元凶とも言える胸腺機能回復に肥満細胞が重要な役割を果たしていることが示唆される研究結果を得た。","subitem_description_type":"Abstract"},{"subitem_description":"Refractory hematological malignancies have been cured by the progress of hematopoietic stem cell transplantation, however graft-versus-host disease (GVHD) is still an obstacle. We have studied the pathophysiology of GVHD using a rodent model to develop new treatments, especially focusing in chronic GVHD probably caused by functional impairments of thymus. In this study, we have indicated that host-typed mast cells are involved in the recovery of thymus function using mast cell deficient mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K09643, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「培養肥満細胞による胸腺機能回復: 骨髄移植における致死的慢性GVHDの制御」課題番号15K09643\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09643/15K09643seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051396","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50324116"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50324116","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09643/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09643/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09643/15K09643seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09643/15K09643seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-18"}],"displaytype":"detail","filename":"HO-PR-NISHIMURA-R-kaken 2018-4p.pdf","filesize":[{"value":"80.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NISHIMURA-R-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45057/files/HO-PR-NISHIMURA-R-kaken 2018-4p.pdf"},"version_id":"ec918800-09b4-4cb1-9ebe-61e4fbfb416c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"培養肥満細胞による胸腺機能回復: 骨髄移植における致死的慢性GVHDの制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養肥満細胞による胸腺機能回復: 骨髄移植における致死的慢性GVHDの制御"},{"subitem_title":"Recovery of thymus function using cultured mast cells: prevention of lethal chronic graft-versus-host disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-18"},"publish_date":"2019-04-18","publish_status":"0","recid":"45057","relation_version_is_last":true,"title":["培養肥満細胞による胸腺機能回復: 骨髄移植における致死的慢性GVHDの制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:49.338787+00:00"}