{"created":"2023-07-27T06:51:34.945323+00:00","id":45060,"links":{},"metadata":{"_buckets":{"deposit":"1277f772-03a9-4f9d-94d6-76a03f1490ea"},"_deposit":{"created_by":18,"id":"45060","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45060"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045060","sets":["2812:2813:2821"]},"author_link":["658","74192"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"家族性地中海熱の原因遺伝子MEFVのG304R変異例では、対照に比べて、exon 2の欠損した短いmRNA量が優位に認められた。G304R変異は、アミノ酸置換を伴うのみならず、選択的スプライシングにより分子量の小さい不完全なpyrin蛋白を多く合成することにより家族性地中海熱を発症することが示唆された。また、患者末梢血単核球をLPS刺激し、培養上清中の炎症性サイトカイン産生を測定した。患者発熱期では、健常対照に比べサイトカイン産生の亢進が認められたが、発作間欠期には著明に低下が認められ、本疾患において発熱が周期性を示す事との関連性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Missense variant G304R in the MEFV gene was associated with predominance of aberrant short mRNA, depleting exon 2. This particular mutation not only results in the amino acid replacement, but also led to excessive exon 2 skipping due to enhanced alternative splicing, with subsequent development of familial Mediterranean fever (FMF). In vitro cytokine production by circulating mononuclear cells was examined after LPS stimulation. During the febrile attacks, cytokine production was significantly increased as compared to normal controls. In contrast, it was markedly suppressed during the interval non-febrile periods. The cyclic patterns of cytokine production may be closely related to the periodicity of the febrile episodes of FMF.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22591152, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「自己炎症疾患における炎症制御機能解析法の開発: 家族性地中海熱をモデルとした研究」課題番号22591152\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591152/22591152seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051399","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00377392"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00377392","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591152/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591152/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591152/22591152seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591152/22591152seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-02"}],"displaytype":"detail","filename":"HO-PR-TOMA-T-kaken 2013-5p.pdf","filesize":[{"value":"419.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TOMA-T-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45060/files/HO-PR-TOMA-T-kaken 2013-5p.pdf"},"version_id":"1edfc709-87b8-4899-9159-d7b45409a825"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自己炎症疾患における炎症制御機能解析法の開発: 家族性地中海熱をモデルとした研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自己炎症疾患における炎症制御機能解析法の開発: 家族性地中海熱をモデルとした研究"},{"subitem_title":"Evaluation of immune-regulatory functions in auto-inflammatory illnesses","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-02"},"publish_date":"2018-07-02","publish_status":"0","recid":"45060","relation_version_is_last":true,"title":["自己炎症疾患における炎症制御機能解析法の開発: 家族性地中海熱をモデルとした研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:16.309681+00:00"}