{"created":"2023-07-27T06:51:35.124543+00:00","id":45064,"links":{},"metadata":{"_buckets":{"deposit":"68054399-d58b-4404-bf6e-e9a259d92197"},"_deposit":{"created_by":18,"id":"45064","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45064"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045064","sets":["2812:2813:2818"]},"author_link":["2407","20219"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regulatory B細胞(制御性B細胞)はIL-10産生を介して免疫反応を抑制する。制御性B細胞を遺伝的に欠くCD19欠損マウスを使用し、強皮症のマウスモデルであるSclerodermatous GVHDマウス（以下、強皮症マウス）を誘導した。CD19欠損マウスは野生型マウスと比べより重症の強皮症マウスを発症した。強皮症マウスに制御性B細胞と他のB細胞をそれぞれ骨髄移植と同日に移植したところ、制御性B細胞を移植した群では強皮症マウスの改善効果が認められた。\nまた、強皮症患者では制御性B細胞が減少しており、病勢を反映していた。以上より制御性B細胞が強皮症の病態に抑制的に働く可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Sclerodermatous cGVHD (Scl-cGVHD) is characterized by fibrosis and autoimmune features resembling those of systemic sclerosis (SSc). Transplantation of B10.D2 bone marrow and splenocytes into irradiated-BALB/c mice is an established model of human Scl-cGVHD. To examine the role of regulatory B cells (Breg cell) in Scl-cGVHD, CD19-deficient (CD19-/-; lack of Breg cell) mice were used as donors or recipients in this model. CD19-/- donors induced more severe Scl-cGVHD than wild-type donors. Adoptive transfer of Breg cells attenuated the augmented manifestations of CD19-/- donor-induced Scl-cGVHD. The frequency of blood Breg cells was significantly lower in patients with SSc, and Breg cell levels inversely correlated with disease activity of SSc. These results suggest that decreased Breg cells contribute to the development of SSc.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461686, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発」課題番号25461686\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461686/25461686seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051403","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60432126"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60432126","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461686/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461686/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461686/25461686seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461686/25461686seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-MATSUSHITA-T-kaken 2016-5p.pdf","filesize":[{"value":"794.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MATSUSHITA-T-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45064/files/HO-PR-MATSUSHITA-T-kaken 2016-5p.pdf"},"version_id":"40263b72-4fde-41c8-ad1d-169410337a26"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発"},{"subitem_title":"The role of regulatory B cell in the pathogenesis of systemic sclerosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45064","relation_version_is_last":true,"title":["全身性強皮症におけるregulatory B細胞の機能解析および新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:37.063033+00:00"}