{"created":"2023-07-27T06:51:35.214176+00:00","id":45066,"links":{},"metadata":{"_buckets":{"deposit":"34ed659f-6db4-4d2b-a40d-5dde7c4203ba"},"_deposit":{"created_by":18,"id":"45066","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45066"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045066","sets":["2812:2813:2823"]},"author_link":["2407","20219"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD19欠損B10.D2マウスの骨髄および脾臓を放射線照射されたBALB/Cマウスに移入(ドナーが制御性B細胞を欠損)した結果は、コントロール群に較べより軽症のSclerodermatous GVHDを発症した。一方、B10.D2マウスの骨髄および脾臓を放射線照射されたCD19欠損BALB/Cマウスに移入(レシピエントが制御性B細胞を欠損)した結果は、コントロール群に較べより重症のSclerodermatous GVHDを発症した。これは、Sclerodermatous GVHDの過程において制御性B細胞が重要な役割を有し、ドノーとレシピエントで働きが違うことが示唆される。特に、制御性B細胞はホストの抑制作用において重要な役割を有していることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"CD19 knockout mouse lack regulatory B cell. Therefore, this mouse is good tool for investigating regulatory B cell. We transferred CD19 knockout B10. D2 bone marrow into Balb/c recipient mice. These mice developed mild sclerodermatous GVHD comparing wildtype mice. While CD19 knockout Balb/c recipient mice which were transferred B10. D2 bone marrow were developed more severe sclerodermatous GVHD than that of wild type mice. These results indicate regulatory B cell is more critical for recipient immune response.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22890073, 研究期間(年度):2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Sclerodermatous GVHDマウスにおける制御性B細胞の役割」課題番号22890073\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22890073/22890073seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051405","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60432126"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60432126","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22890073/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22890073/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22890073/22890073seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22890073/22890073seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-02"}],"displaytype":"detail","filename":"HO-PR-MATSUSHITA-T-kaken 2011-4p.pdf","filesize":[{"value":"219.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MATSUSHITA-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45066/files/HO-PR-MATSUSHITA-T-kaken 2011-4p.pdf"},"version_id":"3ce7deb3-6335-4a37-8b41-81958ca03f63"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Sclerodermatous GVHDマウスにおける制御性B細胞の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sclerodermatous GVHDマウスにおける制御性B細胞の役割"},{"subitem_title":"Research of regulatory B cell role in seclerodermatous GVHD mouse","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-02"},"publish_date":"2018-07-02","publish_status":"0","recid":"45066","relation_version_is_last":true,"title":["Sclerodermatous GVHDマウスにおける制御性B細胞の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:09.682866+00:00"}