{"created":"2023-07-27T06:51:35.438100+00:00","id":45071,"links":{},"metadata":{"_buckets":{"deposit":"25edec2b-98d1-469f-a2bc-3f421de6fcaf"},"_deposit":{"created_by":18,"id":"45071","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45071"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045071","sets":["2812:2813:2822"]},"author_link":["71115","642"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラットやマウスなどの動物研究ではDelta-like protein(DLK)-1が肝プロジェニター/ステム細胞に発現していると報告されており,一方で肝線維化に関連することが知られている肝星細胞でのDLK1発現が文献的に報告されている.ヒト肝組織におけるDLK1発現を分子病理学的に解析した.その結果, DLK1はステム細胞関連と推察される腫瘍で発現しており, DLK1が肝癌ステム細胞のマーカーとなりうる分子であることを解明した.","subitem_description_type":"Abstract"},{"subitem_description":"The expression of Delta-like protein(DLK)-1 in hepatic progenitor/stem cell has been known in animal experiments, whereas the upregulation of DLK1 in hepatic stellate cells has been reported and implied relation to fibrosis. I examined the expression of DLK1 in human tissue. As results, The expression of DLK1 was demonstrated in liver cancer associated with stem-cell origin. It was suggested that DLK1 could be cancer stem-cell marker of the liver.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22790341, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝ステム細胞に関連した肝線維化進展機序の分子病理学的研究」課題番号22790341\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790341/22790341seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051410","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10447675"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10447675","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790341/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790341/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790341/22790341seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790341/22790341seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-IKEDA-H-kaken 2012-4p.pdf","filesize":[{"value":"232.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-IKEDA-H-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45071/files/HO-PR-IKEDA-H-kaken 2012-4p.pdf"},"version_id":"562e14ad-2dec-48aa-9a73-cfe72efe838a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝ステム細胞に関連した肝線維化進展機序の分子病理学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝ステム細胞に関連した肝線維化進展機序の分子病理学的研究"},{"subitem_title":"Research of liver fibrosis associated with liver stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45071","relation_version_is_last":true,"title":["肝ステム細胞に関連した肝線維化進展機序の分子病理学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:50.170373+00:00"}