{"created":"2023-07-27T06:51:35.482131+00:00","id":45072,"links":{},"metadata":{"_buckets":{"deposit":"68f2cffd-442d-46a7-9d53-53c2e19028dd"},"_deposit":{"created_by":18,"id":"45072","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45072"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045072","sets":["2812:2813:2824"]},"author_link":["71115","642"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞老化は不可逆的な細胞周期の停止として定義されており、前癌病変におけるセネッセンス細胞の出現およびセネッセンスからの回避機序は腫瘍発生初期段階での重要なステップであると考えられている。分子病理学的に検討の結果、ヒト肝組織では肝硬変でセネッセンス関連マーカー発現細胞が出現し、肝ディスプラジア結節では消失していた。肝硬変は肝細胞癌の前癌病変である可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Cellular senescence is defined as the irreversible arrest of cell cycle. Senescence in premalignant lesion and escape from senescence are thought to be important the early stage of tumoriogenesis. Senescence-associated markers are observed in cirrhotic liver and the markers disappear in dysplastic nodules. The results imply that the cirrhotic state already might to be premalignancy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「肝細胞癌発生過程における細胞老化の関与とその意義に関する分子病理学的研究」課題番号20790277\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790277/20790277seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051411","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10447675"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10447675","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790277/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790277/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790277/20790277seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790277/20790277seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-IKEDA-H-kaken 2010-4p.pdf","filesize":[{"value":"362.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-IKEDA-H-kaken 2010-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45072/files/HO-PR-IKEDA-H-kaken 2010-4p.pdf"},"version_id":"8ae4259c-9ea9-420e-9c36-77870e928c05"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌発生過程における細胞老化の関与とその意義に関する分子病理学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌発生過程における細胞老化の関与とその意義に関する分子病理学的研究"},{"subitem_title":"Research of cellular senescence in hepatocarcinogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-02"},"publish_date":"2018-07-02","publish_status":"0","recid":"45072","relation_version_is_last":true,"title":["肝細胞癌発生過程における細胞老化の関与とその意義に関する分子病理学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:07.291885+00:00"}