{"created":"2023-07-27T06:51:39.505438+00:00","id":45163,"links":{},"metadata":{"_buckets":{"deposit":"df7b703d-3274-4ca4-a786-e42a0cccbf65"},"_deposit":{"created_by":18,"id":"45163","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45163"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045163","sets":["2812:2813:2816"]},"author_link":["78607","70274"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性腎不全により透析治療を必要とする患者は依然減少しない。腎障害の発症・進展に慢性炎症が関与していることがこれまで示されている。本研究課題では、進行性腎障害における自然免疫の意義を検討した。その結果、自然免疫に深くかかわる、マクロファージの新たな制御因子を見出した。また、ヒト進行性腎障害において、マクロファージより産生されるマクロファージアポトーシス抑制因子(Apoptosis inhibitor of macrophage ：AIM)の沈着が蛋白尿増加、eGFR低下と相関することが明らかとなった。進行性腎障害において、慢性炎症の意義を、マクロファージを中心に解明した。","subitem_description_type":"Abstract"},{"subitem_description":"Chronic inflammation contributes to the progression of kidney disease. We found the novel macrophage regulator molecule, which is involved in progressive kidney injury in mice model. Moreover, Apoptosis inhibitor of macrophage (AIM), which is secreted by macrophage, was detected in various kinds of human kidney disease in kidney biopsy specimen. The deposition of AIM was associated with the increase of proteinuria and the decline of eGFR. These results showed the important role of macrophage in progressive kidney disease both in mouse and human.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K09251, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「進行性腎障害におけるTLR7を介した免疫担当細胞制御の意義」課題番号15K09251\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09251/15K09251seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051502","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90432137"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90432137","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09251/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09251/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09251/15K09251seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09251/15K09251seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-28"}],"displaytype":"detail","filename":"HO-PR-IWATA-Y-kaken 2018-6p.pdf","filesize":[{"value":"576.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-IWATA-Y-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45163/files/HO-PR-IWATA-Y-kaken 2018-6p.pdf"},"version_id":"0a74c52a-44e1-4131-8229-c7e9c23607b4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"進行性腎障害におけるTLR7を介した免疫担当細胞制御の意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"進行性腎障害におけるTLR7を介した免疫担当細胞制御の意義"},{"subitem_title":"Progressive kidney disease and inflammation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-28"},"publish_date":"2019-06-28","publish_status":"0","recid":"45163","relation_version_is_last":true,"title":["進行性腎障害におけるTLR7を介した免疫担当細胞制御の意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:46:43.525178+00:00"}