{"created":"2023-07-27T06:51:39.903173+00:00","id":45172,"links":{},"metadata":{"_buckets":{"deposit":"9fb955b7-21db-4921-b891-ad3e514690d5"},"_deposit":{"created_by":18,"id":"45172","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45172"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045172","sets":["2812:2813:2817"]},"author_link":["21405","2919"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞癌の再発、転移など、難治性に関わる重要な細胞集団として癌幹細胞が知られている。本研究ではEpCAM陽性癌幹細胞における可塑性について、特にがん幹細胞の維持制御機構と微小環境を構成する細胞との関連について検討を行った。線維芽細胞はTGF-betaを分泌しEpCAM陽性癌幹細胞を増加させ、そのメカニズムとしてKDM2Bの発現誘導によるH3K36メチル基のエピジェネティックメモリー制御が考えられた。また癌微小環境を反映すると考えられる６種の血清サイトカインを同定、分子標的薬ソラフェニブの感受性、予後延長効果に関わる可能性を見出した。","subitem_description_type":"Abstract"},{"subitem_description":"Recent evidences suggest that hepatocellular carcinoma possesses cancer stem cells that play a pivotal role on local recurrence and distant organ metastasis after radical treatment. In this study, we found that fibroblasts secrets TGF-beta and induce the stemness in EpCAM+ hepatocellular carcinoma. This effect was mediated at least in part through the activation of H3K36 demethylase KDM2B to modify epigenetic memories and induce the population of EpCAM+ cancer stem cells. We further identified the six cytokines, potentially reflecting the activation of microenvironment of hepatocellular carcinoma, to predict the survival outcome of hepatocellular carcinoma patients who received sorafenib treatment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460994, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝硬変微小環境による肝がん幹細胞発生維持制御機構の解明」研究成果報告書　課題番号26460994\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460994/26460994seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院総合診療部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051511","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90377432"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90377432","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460994/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460994/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460994/26460994seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460994/26460994seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-YAMASHITA-T-kaken 2017-4p.pdf","filesize":[{"value":"216.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YAMASHITA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45172/files/HO-PR-YAMASHITA-T-kaken 2017-4p.pdf"},"version_id":"c78d935d-e6b2-470b-9573-1021bfd72d81"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝硬変微小環境による肝がん幹細胞発生維持制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝硬変微小環境による肝がん幹細胞発生維持制御機構の解明"},{"subitem_title":"Regulation of liver cancer stem cells by cirrhotic liver microenvironment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45172","relation_version_is_last":true,"title":["肝硬変微小環境による肝がん幹細胞発生維持制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:31:32.502509+00:00"}