{"created":"2023-07-27T06:51:40.035465+00:00","id":45177,"links":{},"metadata":{"_buckets":{"deposit":"3e670297-bc3d-4a8d-9657-4354d2ea13a7"},"_deposit":{"created_by":18,"id":"45177","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45177"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045177","sets":["2812:2813:2819"]},"author_link":["21777","78623"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心不全の進展には、心筋細胞死・線維化といった心臓組織のリモデリングが深くかかわっている。骨格筋のサイズを制御する筋特異的ユビキチン連結酵素MAFbxは、心筋において生理的肥大や病的心肥大を制御することが明らかになった。本研究では、より複雑な要因の加わる心筋梗塞後リモデリングにおける役割を検証した。MAFbx遺伝子欠損マウスに心筋梗塞モデルを作成すると、心破裂による死亡が野生型マウスと比較して有意に減少した。MAFbxは心筋梗塞後に生じる心破裂を制御している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Left ventricular (LV) remodeling following myocardial infarction (MI) has an important role on global cardiac function. Muscle atrophy F-box (MAFbx), an E3 ubiquitin ligase, induces skeletal muscle atrophy and cardiac remodeling under the condition of pressure overload, but the roles of MAFbx in MI is not well understood. Our aim is to determine if MAFbx contribute to cardiac remodeling following MI. MAFbx-knockout (KO) and wild-type (WT) mice were subjected to permanent coronary ligation to create MI. The infarct sizes 3 days after MI were not significantly different in WT and MAFbx KO mice. In comparison with WT mice, MAFbx KO mice were protected against early mortality due to cardiac rupture. MMP9 activity in risk areas 3 days after MI was significantly reduced in KO mice than in WT mice.\nMAFbx protein level increase in acute phase after MI. Gene deletion of MAFbx deletion reduces mortality after MI and cardiac rupture, decreasing the activity of MMP9.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「心筋梗塞後リモデリングにおけるタンパク質分解系の役割」課題番号24591092\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591092/24591092seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院循環器内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051516","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50507043"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50507043","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591092/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591092/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591092/24591092seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591092/24591092seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-USUI-S-kaken 2015-4p.pdf","filesize":[{"value":"401.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-USUI-S-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45177/files/HO-PR-USUI-S-kaken 2015-4p.pdf"},"version_id":"3273dc6f-9ab4-4dc0-90d1-02575cf0c8f3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心筋梗塞後リモデリングにおけるタンパク質分解系の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心筋梗塞後リモデリングにおけるタンパク質分解系の役割"},{"subitem_title":"Impacts of Protein Quality Control in Cardiac Remodeling after Myocardial Infarction","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45177","relation_version_is_last":true,"title":["心筋梗塞後リモデリングにおけるタンパク質分解系の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:10.876160+00:00"}