{"created":"2023-07-27T06:51:40.212779+00:00","id":45181,"links":{},"metadata":{"_buckets":{"deposit":"bf3ab203-be27-434c-886f-e443ef60ec94"},"_deposit":{"created_by":18,"id":"45181","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45181"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045181","sets":["2812:2813:2817"]},"author_link":["563","70283"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"線維化は臓器障害に対する過度の創傷治癒反応，すなわち細胞外基質沈着と細胞外基質産生能を有する細胞の集積を特徴とする．しかし，これら過度の創傷治癒反応をもたらす分子生物学的基盤は完全には同定されていない．本研究では、これら過度の創傷治癒反応をもたらす分子生物学的基盤として、脂質メディエーターの一つであるリゾフォスファチジン酸(LPA）およびその受容体LPA1シグナルに着目し、上皮間葉連関を介した臓器線維化にはたす意義の解明を試みた。その結果、尿細管上皮細胞でのLPA-LPA1シグナルが線維芽細胞の増殖や分化を誘導することで、腎線維化進展に寄与することを明らかにし、この知見を論文化した。","subitem_description_type":"Abstract"},{"subitem_description":"Ｆibrosis is charactereized by the expansion of the fibroblast pool, but the mechanisms driving it remain to be fully clarified. We found that lysophosphatidic acid (LPA) and its receptor (LPA1) signaling drives fibroblast proliferation and activation during the development of renal fibrosis by inducing connective tissue growth factor (CTGF). Unilateral ureteral obstruction (UUO)-induced increases in renal collagen were significantly attenuated in LPA1-deficient mice (LPA1-/-) as compared to LPA1-sufficient mice (LPA+/+), as was the accumulations of　fibroblasts. CTGF was detected mainly in tubular epithelial cells, and its levels were suppressed in LPA1-/-. LPA-LPA1 signaling directly induced CTGF expression by primary proximal tubular epithelial cells (PTECs). PTEC-derived CTGF mediated renal fibroblast proliferation and myofibroblast differentiation. These results suggest that targeting LPA-LPA1 signaling could be a therapeutic strategy for renal fibrosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461218, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「上皮-間葉連関に着目したLPA1-MRTF-SRFシグナルの腎線維化にはたす意義」研究成果報告書　課題番号26461218\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461218/26461218seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院血液浄化療法部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051520","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60377421"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60377421","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461218/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461218/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461218/26461218seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461218/26461218seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-SAKAI-Y-kaken 2017-5p.pdf","filesize":[{"value":"186.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SAKAI-Y-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45181/files/HO-PR-SAKAI-Y-kaken 2017-5p.pdf"},"version_id":"7ab99910-ed32-429a-9434-8e65f0bd844c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上皮-間葉連関に着目したLPA1-MRTF-SRFシグナルの腎線維化にはたす意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上皮-間葉連関に着目したLPA1-MRTF-SRFシグナルの腎線維化にはたす意義"},{"subitem_title":"Involvement of LPA1-MRTF-SRF in renal fibrosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45181","relation_version_is_last":true,"title":["上皮-間葉連関に着目したLPA1-MRTF-SRFシグナルの腎線維化にはたす意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:31:29.528324+00:00"}