{"created":"2023-07-27T06:51:40.345221+00:00","id":45184,"links":{},"metadata":{"_buckets":{"deposit":"3347340c-5ea0-46ed-90c4-3c8f8eebbb1f"},"_deposit":{"created_by":18,"id":"45184","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45184"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045184","sets":["2812:2813:2824"]},"author_link":["78635","78634"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心筋虚血再灌流障害において、ケミカルシャペロンである4-フェニル酪酸(4-PBA)が小胞体ストレスを軽減し、梗塞巣の縮小と心機能保持に寄与する可能性を検討した。同様に心筋梗塞モデルにおいても4-PBAが心機能保持に寄与するか否かを検討した。その結果、虚血再灌流モデルにおいて、4-PBAは小胞体ストレスを軽減することで梗塞巣を縮小し、心機能を保持し生存率を改善した。一方心筋梗塞モデルでは4-PBAは線維化を抑制したが心破裂をきたす傾向を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"We assessed the hypothesis that 4-PBA (chemical chaperone) reduces endoplasmic reticulum stress (ER stress) mediated apoptosis and protects against myocardial ischemia-reperfusion injury or myocardial infarction in mice. In result, 4-PBA reduced ER stress mediated apoptosis, decreased infarct size, maintained cardiac function and improved survival ratio in mice with ischemia-reperfusion. On the other hand, 4-PBA inhibited fibrosis and induced cardiac rupture in mice with myocardial infarction.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20790521, 研究期間(年度):2008-2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「マウス心筋虚血再灌流障害および心筋梗塞モデルにおけるケミカルシャペロンの影響」課題番号20790521\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790521/20790521seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院集中治療部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051523","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00361999"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00361999","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790521/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790521/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790521/20790521seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790521/20790521seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-05"}],"displaytype":"detail","filename":"HO-PR-OKAJIMA-M-kaken 2010-5p.pdf","filesize":[{"value":"519.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-OKAJIMA-M-kaken 2010-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45184/files/HO-PR-OKAJIMA-M-kaken 2010-5p.pdf"},"version_id":"d47d0e2e-17b6-4731-a3ed-874b2e9a0154"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マウス心筋虚血再灌流障害および心筋梗塞モデルにおけるケミカルシャペロンの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス心筋虚血再灌流障害および心筋梗塞モデルにおけるケミカルシャペロンの影響"},{"subitem_title":"The effect of chemical chaperone on myocardial ischemia-reperfusion injury and infarction in mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"45184","relation_version_is_last":true,"title":["マウス心筋虚血再灌流障害および心筋梗塞モデルにおけるケミカルシャペロンの影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:04.854562+00:00"}