{"created":"2023-07-27T06:51:41.276385+00:00","id":45205,"links":{},"metadata":{"_buckets":{"deposit":"f7a3c1bc-6f24-4810-9c9a-ad117a9d0fb4"},"_deposit":{"created_by":18,"id":"45205","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45205"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045205","sets":["2812:2813:2823"]},"author_link":["78681","20190"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"白血病細胞及び臼血病細胞由来樹状細胞に発現しているGITRLは,T細胞上のGITRと結合することによって,腫瘍関連抗原であるCDK2に特異的な細胞傷害性T細胞(CTL)の誘導を阻害し,CTL活性も抑制した.また,GITR/GITRL結合によって白血病細胞内ではインドールアミン酸素添加酵素が活性化され,細胞外に分泌されるキヌレニンによってもT細胞の活性化が抑制された.臍帯血移植後に,CDK2ペプチドワクチンと伴に抗GITR抗体,あるいはIDO阻害剤を同時に投与することによって,CDK2特異的CTLが効果的に誘導され,白血病再発を予防出来る可能性が示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"The expression of GITRL was observed both on leukemic cells and leukemic dendritic cells. The binding of GITRL to GITR on T cells inhibited induction of CDK2, One of the leukemia-associated antigens, -specific cytotoxic T cells (CTL) and restrained CTL activity. The GITR/GITRL interaction also increased indoleamine 2, 3-dioxygenase (IDO) activity even in leukemic cells and inducing kynurenine secretion from leukemic cells. The administration of anti-IDO agents or anti-GITRL blocking Abs combined with CDK2 vaccination may therefore effectively induce CDK2-specific CTLs in unrelated cord blood transplantation recipients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20591146, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「臍帯血移植後の移植片対白血病効果誘導を目的とした腫瘍関連抗原ワクチン療法の開発」課題番号20591146\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591146/20591146seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051544","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院血液内科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10322116"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10322116","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591146/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591146/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591146/20591146seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591146/20591146seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-06"}],"displaytype":"detail","filename":"HO-PR-KONDO-Y-kaken 2011-5p.pdf","filesize":[{"value":"247.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KONDO-Y-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45205/files/HO-PR-KONDO-Y-kaken 2011-5p.pdf"},"version_id":"950eeabe-e2c2-4fe9-9af5-32870eba4118"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"臍帯血移植後の移植片対白血病効果誘導を目的とした腫瘍関連抗原ワクチン療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臍帯血移植後の移植片対白血病効果誘導を目的とした腫瘍関連抗原ワクチン療法の開発"},{"subitem_title":"Development of novel tumor-associated antigens peptide vaccine inducing a graft-versus-leukemia effect after umbilical cord blood transplantation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-06"},"publish_date":"2018-07-06","publish_status":"0","recid":"45205","relation_version_is_last":true,"title":["臍帯血移植後の移植片対白血病効果誘導を目的とした腫瘍関連抗原ワクチン療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:06.275130+00:00"}