{"created":"2023-07-27T06:51:41.320344+00:00","id":45206,"links":{},"metadata":{"_buckets":{"deposit":"3149ef66-d94d-4b9c-9ce0-e9adc4e9db6f"},"_deposit":{"created_by":18,"id":"45206","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45206"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045206","sets":["2812:2813:2818"]},"author_link":["594","74052"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"臨床研究（自己脂肪組織由来間質細胞を用いた再生医療に関する臨書研究～虚血性心不全に対して～）実施した際の臨床サンプルを用いて、再生細胞の特性解析、抗サイトカイン効果の解析を実施進めた。\nマウスモデルを用いた検討では、虚血再灌流障害モデルマウスに対して、脂肪組織由来再生細胞投与による心機能改善効果とその機序について解析を進めた。再生細胞投与による炎症性サイトカインの上昇抑制効果とそのシグナルについても解析を進めた。\n上記の結果の一部を、第80回日本循環器学会総会と第15回日本再生医療学会総会において発表した。","subitem_description_type":"Abstract"},{"subitem_description":"The analysis of adipose tissue derived regenerative cell were performed in patients who underwent our clinical study entitled “The Effect of Autologous Adipose Tissue Derived Regenerative Cells to Ischemic Heart Failure Patient”. Part of the beneficial effects to improve the cardiac performance may be related with reduction of inflammatory cytokines such as IL-1B, TNF-A.Also we investigated the effect of adipose tissue derived regenerative cells to myocardial ischemia-reperfusion model mice. And the significant reduction of inflammatory cytokines and improved cardiac function were closely related with the infusion of regenerative cells.\nPart of these findings were presented at The 80th Annual Scientific Meeting of Japanese Circulation Society and The 15th Congress of The Japanese Society for Regenerative Medicine.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461049, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脂肪組織由来間質細胞による心筋再生医療の作用機序に関する研究」課題番号25461049\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461049/25461049seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院循環器内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051545","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60362000"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60362000","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461049/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461049/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461049/25461049seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461049/25461049seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-06"}],"displaytype":"detail","filename":"HO-PR-TAKAMURA-M-kaken 2016-4p.pdf","filesize":[{"value":"185.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKAMURA-M-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45206/files/HO-PR-TAKAMURA-M-kaken 2016-4p.pdf"},"version_id":"1217b6f5-aa4c-4439-8dc8-c549cc1d7b61"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪組織由来間質細胞による心筋再生医療の作用機序に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪組織由来間質細胞による心筋再生医療の作用機序に関する研究"},{"subitem_title":"The Mechanisms of Adipose Tissue Derived Regenerative Cells for Ischemic Heart Failure","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-06"},"publish_date":"2018-07-06","publish_status":"0","recid":"45206","relation_version_is_last":true,"title":["脂肪組織由来間質細胞による心筋再生医療の作用機序に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:30.553208+00:00"}