{"created":"2023-07-27T06:51:41.408587+00:00","id":45208,"links":{},"metadata":{"_buckets":{"deposit":"a3097a6e-cc11-434f-999d-0778565f5092"},"_deposit":{"created_by":18,"id":"45208","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45208"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045208","sets":["2812:2813:2816"]},"author_link":["550","26139"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"長鎖ノンコーディングRNAのC型肝炎ウイルス（HCV)感染における役割を明らかにするため研究を実施した。HCV感染培養細胞のRNAを次世代シークエンサーで解析した所、長鎖ノンコーディングRNAの一つHULCの発現がHCV感染により増加することが明らかになった。HCV感染によるHULCの増加は、HCV感染チンパンジー、HCV感染マウスモデルでも認められた。またHCV感染培養肝細胞でHULCの発現を抑制したところHCV複製の低下を認め、この効果はHCVの翻訳過程の抑制を介していると考えられた。HULCは肝発癌の関与が示唆されており、HCVはHULCの発現を増加し肝発癌を誘発していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the role of long non-coding RNAs in HCV infection. The analysis on RNA of HCV-infected cultured hepatocytes by a next generation sequencer revealed that the RNA level of one of long non-coding RNAs, HULC, increased. The increase of HULC RNA level was observed not only in HCV-infected cultured hepatocytes, but also in an HCV-infected chimpanzee and a HCV-infected mouse. The knockdown of HCV by siRNA suppressed HCV replication as well as infectious virus production in HCV-infected cultured hepatocytes. This effect seemed to occur through the suppression of a translation step among HCV life cycles. Several recent reports show that HULC has the ability to promote hepatocarcinogenesis, therefore, the result of this study suggests a mechanism of hepatocarcinogesis due to HCV infection through HULC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K08492, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「長鎖ノンコーディングRNAを基軸としたC型慢性肝疾患の病態制御」課題番号15K08492\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08492/15K08492seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院地域医療教育センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051547","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50436820"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50436820","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08492/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08492/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08492/15K08492seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08492/15K08492seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-18"}],"displaytype":"detail","filename":"HO-PR-SHIMAKAMI-T-kaken 2018-4p.pdf","filesize":[{"value":"367.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SHIMAKAMI-T-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45208/files/HO-PR-SHIMAKAMI-T-kaken 2018-4p.pdf"},"version_id":"8a211363-aac8-4ee7-aaba-34f8e0531fda"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"長鎖ノンコーディングRNAを基軸としたC型慢性肝疾患の病態制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"長鎖ノンコーディングRNAを基軸としたC型慢性肝疾患の病態制御"},{"subitem_title":"Control of Chronic Liver Diseases due to Hepatitis C Virus by Long Non-coding RNAs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-18"},"publish_date":"2019-04-18","publish_status":"0","recid":"45208","relation_version_is_last":true,"title":["長鎖ノンコーディングRNAを基軸としたC型慢性肝疾患の病態制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:45.068761+00:00"}