{"created":"2023-07-27T06:51:41.452827+00:00","id":45209,"links":{},"metadata":{"_buckets":{"deposit":"13933724-bfc6-4b77-9c2a-507d0b1d68cf"},"_deposit":{"created_by":18,"id":"45209","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45209"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045209","sets":["2812:2813:2819"]},"author_link":["550","26139"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"今後C型慢性肝炎治療はDirect-Acting Antiviral Agents (DAA)耐性ウイルスが問題となる．今回肝特異的に発現するmicroRNA-122 (miR-122)を標的とした抗miR-122療法とDAA併用療法の有用性を検討した．その結果，DAAと抗miR-122療法の併用により相乗的な抗ウイルス効果を示し，DAA耐性ウイルスにDAAと抗miR-122療法を併用することでDAA耐性が改善し, DAAと抗miR-122療法併用によりDAA耐性ウイルスの出現を抑制した．これらの結果から DAAと抗miR-122療法併用は，DAA耐性ウイルスを抑制しうる点で有用と考えられた．","subitem_description_type":"Abstract"},{"subitem_description":"The emergence of Direct-Acting Antiviral Agents (DAA)-resistant virus could be a serious problem for the treatment of chronic hepatitis C patients. We examined the efficiency of the combination therapy with DAA and anti-miR-122 therapy, which is targeting liver-specific miRNA, miR-122. We demonstrated that the combination therapy (1) shows synergistic antiviral effect, (2) alleviates the drug resistance of DAA-resistance viruses, and (3)completely inhibits the emergence of DAA-resistance virus. These results indicate that anti-miR-122 therapy is quite useful in terms of inhibiting the emergence of DAA-resistance virus when it is combined with DAA.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24790687, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発」課題番号24790687\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790687/24790687seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院地域医療教育センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051548","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50436820"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50436820","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790687/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790687/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790687/24790687seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790687/24790687seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-06"}],"displaytype":"detail","filename":"HO-PR-SHIMAKAMI-T-kaken 2015-5p.pdf","filesize":[{"value":"441.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SHIMAKAMI-T-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45209/files/HO-PR-SHIMAKAMI-T-kaken 2015-5p.pdf"},"version_id":"952aad13-2ce5-4db9-843e-269260410ba9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発"},{"subitem_title":"Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus Infection","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-06"},"publish_date":"2018-07-06","publish_status":"0","recid":"45209","relation_version_is_last":true,"title":["抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:09.564972+00:00"}