{"created":"2023-07-27T06:51:41.585992+00:00","id":45212,"links":{},"metadata":{"_buckets":{"deposit":"87fd1263-2477-4ed8-8c0b-15f1fed7d9ff"},"_deposit":{"created_by":18,"id":"45212","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45212"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045212","sets":["2812:2813:2820"]},"author_link":["22112","2648"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"関節炎自然発症マウス（IL-1ra-/-マウス）で、炎症性ケモカインレセプターであるCCR2遺伝子を欠損することで関節炎はむしろ増悪するため、CCR2のリガンドであるMCP-1投与することで関節炎が改善しないか検討した。MCP-1を100pg関節内に投与したところ関節炎はむしろ増悪し、関節内には好中球とマクロファージが増加した。高齢のCCR2を欠損した関節炎発症マウスの関節内サイトカイン、ケモカインタンパク濃度を測定したところ、IL-4、IL-10など抑制性のサイトカイン低下していた。","subitem_description_type":"Abstract"},{"subitem_description":"Previously, we reported that ablation of an inflammatory chemokine receptor, CCR2, led to aggravation of the arthritis of IL-1ra-/- mouse. We assume that MCP-1, the ligand of CCR2, may resolve the arthritis in IL-1ra-/- and injected repeatedly 100pg of MCP-1 into the joint of IL-1ra-/- mouse. Unexpectedly, more severe arthritis was observed after injection of MCP-1, accompanying severe accumulation of neutrophils and macrophages into the joint. Multiplex analysis of cytokine levels in the joint of mature IL-1ra-/-CCR2-/-mouse (20-week-old) revealed decreased levels of regulatory cytokines, such as IL-4 and IL-10, indicating regulatory roles of macrophages during late stage of arthritis. Collectively, CCR2+ macrophages may serve as pro-inflammatory during early stage and later, as anti-inflammatory during late stage of arthritis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24790995, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ケモカインによる関節炎の制御」課題番号24790995\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790995/24790995seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051551","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院リウマチ・膠原病内科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20596895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20596895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790995/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790995/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790995/24790995seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790995/24790995seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-06"}],"displaytype":"detail","filename":"HO-PR-FUJII-H-kaken 2014-4p.pdf","filesize":[{"value":"106.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-FUJII-H-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45212/files/HO-PR-FUJII-H-kaken 2014-4p.pdf"},"version_id":"539531e0-9d7b-4cf7-b947-3bcfa1a2fc43"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ケモカインによる関節炎の制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ケモカインによる関節炎の制御"},{"subitem_title":"Effect of intra-articular injection of MCP-1 on arthritis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-06"},"publish_date":"2018-07-06","publish_status":"0","recid":"45212","relation_version_is_last":true,"title":["ケモカインによる関節炎の制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:46.299268+00:00"}