{"created":"2023-07-27T06:51:41.720802+00:00","id":45215,"links":{},"metadata":{"_buckets":{"deposit":"a8f0ca0f-eaf1-49e7-a8c8-c74f4a14ad3f"},"_deposit":{"created_by":18,"id":"45215","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45215"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045215","sets":["2812:2813:2816"]},"author_link":["2483","23450"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪由来幹細胞は皮下脂肪組織から容易に採取可能で，小侵襲かつ大量に培養できるという利点があるため，臨床応用を目指して様々な研究が行われている．本研究では，セルシート技術を用いて大量の脂肪由来幹細胞を家兎変形性膝関節症モデルに移植することで，軟骨変性に与える影響について検討した。\n実験結果から，シート移植により軟骨変性が軽減され，さらに，コラゲナーゼやアグリカナーゼ（組織を破壊する酵素のこと）の発現が有意に抑制されていた．つまり，移植した脂肪由来幹細胞が軟骨基質保護作用を持つ液性因子を分泌し，変形性膝関節症の進行を予防したと考えられる．","subitem_description_type":"Abstract"},{"subitem_description":"Adipose-derived stem cells (ADSCs) can easily be isolated from subcutaneous adipose tissue and cultured in large quantities with a minimally invasive procedure. So, our study team has investigated them in various fields such as bones, cartilages, peripheral nerves, menisci and ligaments. The purpose of this study was to determine whether intra-articularly injected ADSC sheets inhibited articular cartilage degeneration during osteoarthritis(OA) development in a rabbit anterior cruciate ligament transection (ACLT) model.\nOur study showed that the OA progression was milder in the ADSC sheets group. Furthermore, collagenases (MMP-1, MMP-13) and aggrecanase (ADAMTS-4) were less expressive in the same group. So, we suggested that the ADSCs inhibited progression of articular cartilage degeneration by secreting liquid factors having chondro-protective effects. To the best of our knowledge, our study is the first to prove the role of ADSC sheets in the treatment of OA.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K10465, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「変形性関節症の軟骨損傷に対する脂肪由来幹細胞を用いた予防と治療に関する基礎実験」課題番号15K10465\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10465/15K10465seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院リハビリテーション部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051554","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10334749"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10334749","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10465/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10465/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10465/15K10465seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10465/15K10465seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-18"}],"displaytype":"detail","filename":"HO-PR-KABATA-T-kaken 2018-5p.pdf","filesize":[{"value":"404.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KABATA-T-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45215/files/HO-PR-KABATA-T-kaken 2018-5p.pdf"},"version_id":"47f1babf-eec4-406d-82b1-744c58721ba2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"変形性関節症の軟骨損傷に対する脂肪由来幹細胞を用いた予防と治療に関する基礎実験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"変形性関節症の軟骨損傷に対する脂肪由来幹細胞を用いた予防と治療に関する基礎実験"},{"subitem_title":"Periodic injections of adipose-derived stem cell sheets inhibit osteoarthritis progression in an experimental rabbit model","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-18"},"publish_date":"2019-04-18","publish_status":"0","recid":"45215","relation_version_is_last":true,"title":["変形性関節症の軟骨損傷に対する脂肪由来幹細胞を用いた予防と治療に関する基礎実験"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:43.631313+00:00"}