{"created":"2023-07-27T06:51:42.078971+00:00","id":45223,"links":{},"metadata":{"_buckets":{"deposit":"bd453479-b0b5-4f57-9719-4d37d1cf3827"},"_deposit":{"created_by":18,"id":"45223","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45223"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045223","sets":["2812:2813:2817"]},"author_link":["70371","337"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、マウス非培養脂肪組織由来間質細胞群の細胞分画を解析し、その特性を検討した。また、マウス肝疾患モデルを用いて、肝疾患状態に対する効果を検討した。非培養脂肪組織由来間質細胞群には、約10～20%のCD45陽性細胞が存在した。CD45陽性細胞は、表面抗原発現解析、遺伝子発現より、M2フェノタイプマクロファージ様の特性を有することを明らかとした。急性肝炎マウスに対する非培養脂肪由来間質細胞群、間質細胞群のCD45陽性細胞分画の投与による治療効果を確認した。非培養脂肪組織由来間質細胞群のCD45陽性細胞分画の炎症修飾能における重要性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we analyzed the cellular fractions of murine uncultured adipose tissue derived stromal cells and assessed their characteristics. In addition, we investigated their effect on the liver disease condition using murine liver disease models. We found that the 10-20% of uncultured adipose tissue-derived stromal cells expressed CD45 antigen. CD45+ cells were disclosed to be characteristics of M2 phenotype macrophage in view of surface antigen analysis as well as gene expression analysis. Administration of the entire ulcutred adipose tissue derived stromal cells and their CD45+ fraction were effective to acute murine hepatitis. Thus, these results indicated that the relative importance of CD45+ cellular fraction of the uncultured adipose tissue derived stromal cells in the context of their immunomodulatory effect.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460995, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「脂肪組織由来間質細胞群の細胞分画特性解析と肝修復再生療法の開発」研究成果報告書　課題番号26460995\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460995/26460995seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051562","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80401925"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80401925","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460995/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460995/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460995/26460995seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460995/26460995seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-SAKAI-Y-kaken 2017-6p.pdf","filesize":[{"value":"103.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKAI-Y-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45223/files/ME-PR-SAKAI-Y-kaken 2017-6p.pdf"},"version_id":"88151d0a-83ea-46f2-a571-f0addcd161c3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪組織由来間質細胞群の細胞分画特性解析と肝修復再生療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪組織由来間質細胞群の細胞分画特性解析と肝修復再生療法の開発"},{"subitem_title":"Analysis of characteristics of cellular subfractions in adipose tissue-derived stromal cells for development of liver repair/regenerative therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45223","relation_version_is_last":true,"title":["脂肪組織由来間質細胞群の細胞分画特性解析と肝修復再生療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:26:18.608343+00:00"}