{"created":"2023-07-27T06:51:42.395959+00:00","id":45230,"links":{},"metadata":{"_buckets":{"deposit":"d22ffbeb-f7a1-400b-a536-f898f52ae97e"},"_deposit":{"created_by":18,"id":"45230","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45230"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045230","sets":["2812:2813:2817"]},"author_link":["31","78713"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究従事者らはこれまで母体の免疫細胞が胚からのシグナルを受けて機能を変化させ、黄体と子宮内膜の分化を促進して胚の着床を誘導することを見出してきた。本研究では胚のシグナルとして透明帯およびHCGホルモンの糖鎖構造が重要であることを提言し、さらにヒト絨毛細胞が特異的に産生するlaeverinが新しい胚シグナルである可能性を示した。これらの成果は新しい視点からの着床不全に対する治療法の開発に貢献することが期待される。","subitem_description_type":"Abstract"},{"subitem_description":"We found that maternal immune systems change their function to induce corpus luteum and endometrial differentiation, leading to embryo implantation. This project further demonstrated the importance of zona pellucida and HCG as embryonal signals and proposed that laeverin, which is specifically produced by human extravillous trophoblast, is a new candidate for embryonal signas. We hope that these findings will contribute to developing a new therapy for patients with repeated implantation failure.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26293358, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「胚由来の胚着床誘導因子(胚シグナル)の同定と臨床応用への試み」研究成果報告書　課題番号26293358\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293358/26293358seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051569","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293358/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293358/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293358/26293358seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293358/26293358seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2017-5p.pdf","filesize":[{"value":"273.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45230/files/ME-PR-FUJIWARA-H-kaken 2017-5p.pdf"},"version_id":"7e70482a-93a6-4019-8fa3-0a59dba0c6eb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胚由来の胚着床誘導因子(胚シグナル)の同定と臨床応用への試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胚由来の胚着床誘導因子(胚シグナル)の同定と臨床応用への試み"},{"subitem_title":"Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45230","relation_version_is_last":true,"title":["胚由来の胚着床誘導因子(胚シグナル)の同定と臨床応用への試み"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:26:12.385850+00:00"}