{"created":"2023-07-27T06:51:42.441587+00:00","id":45231,"links":{},"metadata":{"_buckets":{"deposit":"399ba8fd-2917-4533-b952-92b90f79c915"},"_deposit":{"created_by":18,"id":"45231","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45231"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045231","sets":["2812:2813:2819"]},"author_link":["31","78713"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は「血小板から放出される因子によって子宮内膜上皮の遊走と再構築が誘導され、その機構の異常が婦人科疾患の発症と進展を誘導している」という新しい作業仮説のもとに計画された。その結果、血小板中のケモカインが子宮内膜上皮細胞と子宮体癌由来Ishikawa細胞を促進すること、その一方で血小板から放出される細胞膜小粒子は正常子宮内膜上皮細胞の遊走を反対に抑制し、さらに上皮の再構築を亢進する可能性が示された。細胞膜小粒子による作用は癌細胞株では観察されなかった。これらの成果は種々の婦人科疾患の発症や癌の進展に対する新しい治療法の開発に貢献する可能性があり、今後も解析すべき課題であると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"We designed this study based on the novel concept that platelet-derived factors induce endometrial epithelial cell migration and epithelial construction and its failure can cause onset and development of gynecological disorders. This study showed that the platelets promoted cell attachment of a human endometrial epithelial cell-derived immortalized cell line (EM-E6/E7/hTERT). Platelets inhibited, but the platelet-conditioned medium excluding the microparticle promoted EM-E6/E7/hTERT cell invasion. On the other hand, the platelet enhanced the human endometrial carcinoma-derived cell lines, Ishikawa cells and HEC-1 cells. These results indicate the possible involvement of platelets in endometrial epithelial regeneration and suggest differences in the responses to the re-epithelialization-inducing effects of platelet-derived microparticles between normal endometrial epithelial cells and cancer cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25670702, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「血小板による新しい再上皮化誘導機構とその異常」課題番号25670702\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670702/25670702seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670702/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670702/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670702/25670702seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670702/25670702seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2015-5p.pdf","filesize":[{"value":"115.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45231/files/ME-PR-FUJIWARA-H-kaken 2015-5p.pdf"},"version_id":"d7559a6c-c0d3-4302-ae7b-2179a362950e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血小板による新しい再上皮化誘導機構とその異常","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血小板による新しい再上皮化誘導機構とその異常"},{"subitem_title":"Platelet-induced re-epithelialization and its failure","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45231","relation_version_is_last":true,"title":["血小板による新しい再上皮化誘導機構とその異常"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:06.413013+00:00"}