{"created":"2023-07-27T06:51:42.487531+00:00","id":45232,"links":{},"metadata":{"_buckets":{"deposit":"52ae8fb0-2c78-4300-a054-11062b66154b"},"_deposit":{"created_by":18,"id":"45232","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45232"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045232","sets":["2812:2813:2821"]},"author_link":["31","78713"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトの胎盤形成過程において絨毛外栄養膜細胞は母体の子宮内膜に浸潤してラセン動脈を再構築する。本研究では研究申請者らが絨毛外栄養膜細胞に特異的に発現する分子として同定したlaeverin ついて、特にその生理的役割を解析する目的で計画された。その結果、soluble formのlaeverinがmonocyteのdendritic cellへの分化を誘導し、HLA-Gとともに絨毛外栄養膜細胞に対する免疫寛容誘導にも関与している可能性が示された。これらの知見は胚や胎児の子宮内発育を可能とする機構を説明する上で重要な機序を示唆しており、臓器移植分野への応用も視野に入れてさらに検討すべき研究課題であると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24659730, 研究期間(年度):2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒト栄養膜細胞に特異的な新規液性因子laeverinによる免疫寛容誘導機構の解析」課題番号24659730\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659730/24659730seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051571","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659730/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659730/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659730/24659730seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659730/24659730seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2013-4p.pdf","filesize":[{"value":"268.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45232/files/ME-PR-FUJIWARA-H-kaken 2013-4p.pdf"},"version_id":"870f2f50-310b-4198-b173-22aa81a8efc4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト栄養膜細胞に特異的な新規液性因子laeverinによる免疫寛容誘導機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト栄養膜細胞に特異的な新規液性因子laeverinによる免疫寛容誘導機構の解析"},{"subitem_title":"Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45232","relation_version_is_last":true,"title":["ヒト栄養膜細胞に特異的な新規液性因子laeverinによる免疫寛容誘導機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:13.490348+00:00"}