{"created":"2023-07-27T06:51:42.577693+00:00","id":45234,"links":{},"metadata":{"_buckets":{"deposit":"88b6d20a-345d-402d-803a-968cdf5f1c70"},"_deposit":{"created_by":18,"id":"45234","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45234"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045234","sets":["2812:2813:2820"]},"author_link":["31","78713"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は透明帯の分解産物が胚特異的な糖鎖構造を介して母体に胚存在の情報を伝達する仮説に基づき計画された。具体的には、透明帯の免疫細胞に対する作用および傍大動脈リンパ節への伝達様式を検討し、さらに末梢血免疫細胞と血小板の子宮内膜とtrophoblastへの作用およびlaeverinの免疫細胞への作用を解析した。その結果、マウス透明帯で活性化する細胞群が観察され、またlaeverinが妊娠初期から分泌されること、さらにHLA-Gとともに胚の免疫寛容獲得に関与している可能性が示され、laeverinが子宮組織に浸潤していく絨毛外栄養膜細胞からの新規の胚シグナルであることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"This project was based on the hypothesis that embryo transmits the information of their presence to maternal immune system using degenerated products of zona pellucida (Dp-ZP). In this study, we examined the effects of Dp-ZP on immune cell function and the transmitting system to para-aortic lymph nodes, and the effects of peripheral immune cells, platelets and laeverin on endometrial and trophoblast functions. As results, we found that murine zona pellucida could activate immune cells. In addition, we observed that laeverin was secreted from chorionic villi at very early stage, showing the possibility that it is related with induction of immune tolerance in concert with HLA-G. These findings suggest that laeverin is a novel embryonic signal secreted from extravillous trophoblast that invades the uterus.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23390389, 研究期間(年度):2011-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胚特異的糖鎖抗原を介した母体の胚認識および胚着床・胎盤形成誘導機構の解析」課題番号23390389\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390389/23390389seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051573","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390389/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390389/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390389/23390389seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390389/23390389seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2014-6p.pdf","filesize":[{"value":"259.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45234/files/ME-PR-FUJIWARA-H-kaken 2014-6p.pdf"},"version_id":"c893fd59-86d5-465f-a378-8fef9cfdc349"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胚特異的糖鎖抗原を介した母体の胚認識および胚着床・胎盤形成誘導機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胚特異的糖鎖抗原を介した母体の胚認識および胚着床・胎盤形成誘導機構の解析"},{"subitem_title":"Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placetation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45234","relation_version_is_last":true,"title":["胚特異的糖鎖抗原を介した母体の胚認識および胚着床・胎盤形成誘導機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:42.344780+00:00"}