{"created":"2023-07-27T06:51:42.712280+00:00","id":45237,"links":{},"metadata":{"_buckets":{"deposit":"73864451-8e7b-4d0f-9e90-e4b5496874c0"},"_deposit":{"created_by":18,"id":"45237","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45237"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045237","sets":["2812:2813:2821"]},"author_link":["78721","2081"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EBウイルスの癌蛋白であるLMP1はそのような多くの分子を誘導し上咽頭癌の高転移性に寄与していると考えられているが、その詳しいメカニズムは不明である。近年、核内タンパクであるSATB1がDNAの遺伝子発現に深く関与し、多くの遺伝子発現を制御することが報告された。我々はLMP1とSATB1の上咽頭培養細胞および上咽頭癌組織標本での相互作用を検討した。上咽頭培養細胞においてLMP1を形質導入するとSATB1の誘導が確認された。上咽頭癌組織標本において免疫組織学的検討から、LMP1の発現とSATB1の発現も有意に相関していた。以上から上咽頭癌においてLMP1はSATB1を通して細胞増殖、アポトーシスを制御していることが示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines.We show that SATB1 protein levels are elevated in tissue samplesfrom patients with nasopharyngeal carcinoma (NPC). Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22791579, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「上咽頭癌における細胞接着シグナリング機構の解明」課題番号22791579\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791579/22791579seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051576","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院耳鼻咽喉科・頭頸部外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30547154"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30547154","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791579/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791579/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791579/22791579seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791579/22791579seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-ENDO-K-kaken 2013-4p.pdf","filesize":[{"value":"338.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-ENDO-K-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45237/files/HO-PR-ENDO-K-kaken 2013-4p.pdf"},"version_id":"886c8fa7-4073-43ee-8158-6a637144f3dc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上咽頭癌における細胞接着シグナリング機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上咽頭癌における細胞接着シグナリング機構の解明"},{"subitem_title":"Research of signaling mechanism in nasopharyngeal cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45237","relation_version_is_last":true,"title":["上咽頭癌における細胞接着シグナリング機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:12.058989+00:00"}