{"created":"2023-07-27T06:51:42.802657+00:00","id":45239,"links":{},"metadata":{"_buckets":{"deposit":"107224e3-3d80-47b8-9b20-393d14ad9c85"},"_deposit":{"created_by":18,"id":"45239","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45239"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045239","sets":["2812:2813:2818"]},"author_link":["2011","21455"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SATB1は、ゲノムのマスターレギュレーターとして1000種類以上の遺伝子発現の上流に位置する。SATB1発現により、乳癌では癌の増殖・浸潤・転移に関与する多数の遺伝子を活性化する。しかし、頭頸部癌におけるSATB1発現は研究されていない。\n本研究では、上咽頭癌組織において、SATB1の発現が高いと高転移性となる事が判明した。また、EBウイルスLMP1導入した細胞ではSATB1が誘導され、形質転換とアポトーシス抵抗性に関与していた。上咽頭癌以外の頭頸部癌組織の解析では、中咽頭癌でSATB1発現が亢進していた。これらから、SATB1は頭頸部癌で癌の増殖・浸潤・転移に関与することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"SATB1 is a master regulator that regulates thousand kinds of gene expressions. SATB1 associates cancer progression, invasion, and metastasis in mammalian cancer. SATB1 activates various gene expressions in mammalian cancer. However, there has been no reports that examine SATB1 expression in head and neck cancer.\nIn this study, we found that Epstein-Barr virus latent membrane protein-1 (EBV-LMP1) expression correlates with SATB1 expression in sample tissues with nasopharyngeal carcinoma. Moreover, we found EBV-LMP1 induces SATB1 expression in epithelial cell lines. In addition, SATB1 induced by EBV-LMP1 correlates transformation and anti-apoptosis. Finally, we also examined that SATB1 expression in other head and neck cancers and we found that SATB1 expression level of oropharygeal cancer (OPC) is higher than that of other cancers.　These finding suggest SATB1 associates cancer progression, invasion, and metastasis in head and neck cancers.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25670713, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「遺伝子マスターレギュレーターSATB1の頭頸部癌遺伝子発現制御機構」課題番号25670713\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670713/25670713seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院耳鼻咽喉科・頭頸部外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051578","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70436822"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70436822","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670713/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670713/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670713/25670713seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670713/25670713seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-KONDO-S-kaken 2016-5p.pdf","filesize":[{"value":"282.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KONDO-S-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45239/files/HO-PR-KONDO-S-kaken 2016-5p.pdf"},"version_id":"35284374-82fa-4053-a199-c48b9071dc6e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝子マスターレギュレーターSATB1の頭頸部癌遺伝子発現制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝子マスターレギュレーターSATB1の頭頸部癌遺伝子発現制御機構"},{"subitem_title":"A master regulator, SATB1, regulates genes expressions in head and neck cancers","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45239","relation_version_is_last":true,"title":["遺伝子マスターレギュレーターSATB1の頭頸部癌遺伝子発現制御機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:23.742116+00:00"}