{"created":"2023-07-27T06:51:42.847383+00:00","id":45240,"links":{},"metadata":{"_buckets":{"deposit":"e4f6a174-4141-4274-9482-7830ff856bf3"},"_deposit":{"created_by":18,"id":"45240","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45240"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045240","sets":["2812:2813:2818"]},"author_link":["2011","21455"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌組織は、少数の癌幹細胞と多数の分化細胞から構成される「癌幹細胞」理論が提唱された。我々は、Epstein-Barrウィルス (EBV)遺伝子を用い、上咽頭癌の癌幹細胞作成に成功した。\n他方、癌細胞増殖は、周囲の正常細胞との相互作用「細胞競合」により規定されることが報告された。本研究では、「正常細胞」「前癌病変細胞」「癌細胞」「癌幹細胞」を作成し、細胞競合現象を検討した。いずれの共培養でも細胞競合は起こった。上咽頭癌組織・細胞モデルにおいて、細胞競合マーカーのSparc発現低下と、周囲の正常組織でSparcの発現亢進を認めた。これらからSparcは細胞競合に強く関連していることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In recent study, new theory has been proposed that cancer tissues composed by a few “cancer stem cells” which can generate cancer cells, and many “differentiated cancer cells”. From this theory, we reported　Epstein-Barr virus (EBV) genes could induce cancer stem cells of nasophraryngeal carcinoma (NPC) .\nOn the other hand, it is reported that cancer proliferation is regulated by “cell competition”, interaction between normal cells surrounding cancer cells and cancer cells. In this study, we generate “ normal cell”, “precancerous cell”, “cancer cell”, and “cancer stem cell” using plasmid that contains EBV gene and other precancerous NPC genes. Finally, we examined cell competition phenomena between these cell lines. We detected cell competition phenomena in every co-culture of these cells. In NPC tissues and cell lines, we found that high Sparc expression in normal cells. These finding suggest that Sparc is closely related cell competition.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24689064, 研究期間(年度):2012-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞競合現象に基づく上咽頭癌発癌機構の解析と新規治療法の開発」課題番号24689064\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24689064/24689064seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院耳鼻咽喉科・頭頸部外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051579","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70436822"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70436822","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24689064/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24689064/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24689064/24689064seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24689064/24689064seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-KONDO-S-kaken 2016A-5p.pdf","filesize":[{"value":"261.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KONDO-S-kaken 2016A-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45240/files/HO-PR-KONDO-S-kaken 2016A-5p.pdf"},"version_id":"21d8a161-63f9-49ab-8b29-52a060670688"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞競合現象に基づく上咽頭癌発癌機構の解析と新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞競合現象に基づく上咽頭癌発癌機構の解析と新規治療法の開発"},{"subitem_title":"Establishment new therapy and analysis of carcinogenesis of nasopharyngeal carcinoma by cell competition","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45240","relation_version_is_last":true,"title":["細胞競合現象に基づく上咽頭癌発癌機構の解析と新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:22.509785+00:00"}