{"created":"2023-07-27T06:51:43.071554+00:00","id":45245,"links":{},"metadata":{"_buckets":{"deposit":"990a0a1d-27af-45aa-9e0a-e987c5b0e288"},"_deposit":{"created_by":18,"id":"45245","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45245"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045245","sets":["2812:2813:2823"]},"author_link":["21815","1956"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は出生直後のHearing onset前に、ヒトの先天聾に類似したラセン神経節細胞の破壊を伴わない状態での先天難聴動物モデルを作成し、Hearing onsetが起こらないということが、その後の聴覚中枢の発達に及ぼす影響について検討するものである。\n今回ヒトの先天聾に類似した、画期的な先天聾動物モデルを作成することに成功した。作成したモデルは2種類で、(1)外科的内耳破壊モデル:冷凍麻酔下に生後1～3日目に蝸牛骨包を解放し、アブミ骨を除去した上で内耳(前庭階)を直接吸引するもの、(2)薬剤性内耳障害モデル:ラットのHearing onsetは生後12日目頃なので、生後1日目から10日間内耳毒性抗菌薬のカナマイシンを仔に腹腔内全身投与したものである。今後はこのモデルを用い、「Hearing onsetがない」ということが、聴覚中枢の正常発達に何らかの影響を及ぼすか否かについて検討する予定である。","subitem_description_type":"Abstract"},{"subitem_description":"Hearing loss produced by cochlear damage during early development can result in persistent changes in organization of the central auditory system in adults.\nIn this research, we successfully made rats model with unilateral cochlear ablation conducted prior to the onset of hearig. Our next research is to investigate the neurochemical and neuroanatomical changes produced in auditory brainstem of these rats.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「聴覚中枢発達の解明」課題番号21890088\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890088/21890088seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院耳鼻咽喉科・頭頸部外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051584","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20547179"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20547179","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21890088/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21890088/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890088/21890088seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21890088/21890088seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-SUGIMOTO-N-kaken 2011-4p.pdf","filesize":[{"value":"204.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SUGIMOTO-N-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45245/files/ME-PR-SUGIMOTO-N-kaken 2011-4p.pdf"},"version_id":"31617b76-6969-44eb-a888-af2f335b068a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"聴覚中枢発達の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"聴覚中枢発達の解明"},{"subitem_title":"Research of central auditory system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45245","relation_version_is_last":true,"title":["聴覚中枢発達の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:03.538367+00:00"}