{"created":"2023-07-27T06:51:43.251246+00:00","id":45249,"links":{},"metadata":{"_buckets":{"deposit":"5726a252-a2d5-48eb-ab92-3e7331802f01"},"_deposit":{"created_by":18,"id":"45249","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45249"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045249","sets":["2812:2813:2821"]},"author_link":["24503","3004"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、口腔癌幹細胞ニッチで幹細胞性維持に関わるプロテアーゼについて、癌増殖・浸潤・転移に重要でかつ細胞外マトリックスに高い分解活性を持つMMPとADAM にターゲットを絞って解析する。これらのプロテアーゼファミリーに特異的なインヒビターを発現するトランスジェニックマウスを用いて、どのプロテアーゼが癌幹細胞のニッチからの離脱に関わるのかを生体内で明らかにする。","subitem_description_type":"Abstract"},{"subitem_description":"In oral tumor micro environment (stem cell niche), the role of extracellular matrix degradation enzymes, MMP and ADAM which is critical for tumor invasion and metastasis, is not clear. To address this question, we establish transgenic mice which overexpress MMP or ADAM specific inhibitor in niche cells specifically, and try to identify which protease is involved in regulation of oral tumor micro environment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22592030, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「口腔癌幹細胞と癌の微小環境(ニッチ)におけるMMPおよびADAMの役割検討」課題番号22592030\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22592030/22592030seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051588","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30542253"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30542253","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592030/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592030/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22592030/22592030seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22592030/22592030seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 2013-5p.pdf","filesize":[{"value":"195.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45249/files/ME-PR-NAKAMURA-H-kaken 2013-5p.pdf"},"version_id":"6ceac8f4-5d8d-47b8-9eab-8f7cea555d9c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔癌幹細胞と癌の微小環境(ニッチ)におけるMMPおよびADAMの役割検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔癌幹細胞と癌の微小環境(ニッチ)におけるMMPおよびADAMの役割検討"},{"subitem_title":"The role of extracellular matrix degradation enzymes, MMP and ADAM in tumor micro environment (stem cell niche)","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45249","relation_version_is_last":true,"title":["口腔癌幹細胞と癌の微小環境(ニッチ)におけるMMPおよびADAMの役割検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:10.741388+00:00"}