{"created":"2023-07-27T06:51:43.384920+00:00","id":45252,"links":{},"metadata":{"_buckets":{"deposit":"94b4e6bd-4d57-4f24-87db-e56b651c8ad1"},"_deposit":{"created_by":18,"id":"45252","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45252"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045252","sets":["2812:2813:2818"]},"author_link":["520","21488"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"申請者はこれまでに、肝由来分泌タンパクセレノプロテインP(SeP)がインスリン抵抗性を誘導して高血糖を発症させるヘパトカインであることを報告した。本研究では、SePによる運動療法抵抗性の発症という新たな病態概念を提唱した。筋管細胞において、SePが活性酸素依存性AMPKリン酸化を減弱すること、SeP欠損マウスの運動感受性が亢進していること、SePの筋受容体がLRP1であることを見出した。SePの過剰は受容体LRP1を介して筋で活性酸素/AMPK経路を抑制することで“運動抵抗性”を惹起する。SeP/LRP1の阻害薬は運動療法の感受性を増強させる新たな2型糖尿病治療薬となる可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"We have previously identified selenoprotein P (SeP) as a type 2 diabetes-upregulated hepatokine that induces insulin resistance and hyperglycemia. In this study, we propose a novel pathological concept SeP-induced exercise resistance. We have found out that SeP impairs ROS-induced AMPK phosphorylation in cultured myotubes. SeP knockout mice showed increased sensitivity to exercise training. siRNA screening revealed that LRP1 functions as a SeP receptor in cultured myotubes. This study demonstrates that overproduction of SeP induces exercise resistance by suppressing ROS/AMPK through muscle receptor LRP1. Our study opens the door for inhibitors of SeP/LRP1 axis as new drugs for physical inactivity-associated diseases such as type 2 diabetes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461334, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヘパトカインセレノプロテインPによる運動療法抵抗性誘導機構の解明」課題番号25461334\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461334/25461334seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051591","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80447680"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80447680","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461334/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461334/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461334/25461334seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461334/25461334seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-MISU-H-kaken 2016-5p.pdf","filesize":[{"value":"142.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MISU-H-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45252/files/ME-PR-MISU-H-kaken 2016-5p.pdf"},"version_id":"97ba2dd0-a654-48ff-8cd5-83235d647362"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヘパトカインセレノプロテインPによる運動療法抵抗性誘導機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘパトカインセレノプロテインPによる運動療法抵抗性誘導機構の解明"},{"subitem_title":"Investigation of exercise resistance induced by hepatokine selenoprotein P","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45252","relation_version_is_last":true,"title":["ヘパトカインセレノプロテインPによる運動療法抵抗性誘導機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:19.615668+00:00"}