{"created":"2023-07-27T06:51:43.429775+00:00","id":45253,"links":{},"metadata":{"_buckets":{"deposit":"82e3c356-6706-4534-84a1-f8b9710f80ea"},"_deposit":{"created_by":18,"id":"45253","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45253"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045253","sets":["2812:2813:2821"]},"author_link":["520","21488"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗糖尿病薬メトフォルミンがAMPキナーゼ/Foxo3経路を介して肝細胞でインスリン抵抗性誘導へパトカインであるセレノプロテインPの遺伝子発現を減弱させることを見出した。C2C12筋細胞において、セレノプロテインP受容体の強い候補として膜タンパク候補1を同定した。今後、肝でのAMPキナーゼ/Foxo3経路および筋でのセレノプロテインP/膜タンパク候補1経路が新たな2型糖尿病の治療標的になることが期待される。","subitem_description_type":"Abstract"},{"subitem_description":"Antidiabetic drug metformin was shown to reduce selenoprotein P gene expression via AMP kinase/Foxo3 pathway in the cultured hepatocytes. Membrane protein X was identified as a strong candidate of the receptor of selenoprotein P in C2C12 myocytes. It is expected that AMPK/Foxo3 pathway in the liver and seenoprotein P/membrane protein 1 pathway in the muscle are novel therapeutic targets for type 2 diabetes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23791022, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新規インスリン抵抗性ヘパトカインセレノプロテインPを標的とした糖尿病治療法の探索」課題番号23791022\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791022/23791022seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051592","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80447680"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80447680","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791022/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791022/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791022/23791022seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791022/23791022seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"ME-PR-MISU-H-kaken 2013-5p.pdf","filesize":[{"value":"508.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MISU-H-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45253/files/ME-PR-MISU-H-kaken 2013-5p.pdf"},"version_id":"5e5ceb37-f8e7-4f11-864b-cf655194189e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規インスリン抵抗性ヘパトカインセレノプロテインPを標的とした糖尿病治療法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規インスリン抵抗性ヘパトカインセレノプロテインPを標的とした糖尿病治療法の探索"},{"subitem_title":"Screening for therapies of diabetes targeting novel hepatokine selenoprotein P that induces insulin resistance","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45253","relation_version_is_last":true,"title":["新規インスリン抵抗性ヘパトカインセレノプロテインPを標的とした糖尿病治療法の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:37:09.372992+00:00"}