{"created":"2023-07-27T06:51:43.695850+00:00","id":45262,"links":{},"metadata":{"_buckets":{"deposit":"388db514-d385-4695-8bd4-8d58ded08882"},"_deposit":{"created_by":18,"id":"45262","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45262"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045262","sets":["2812:2813:2816"]},"author_link":["1721","24303"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮内膜癌154例にp53とER(α/β)について免疫組織学的に解析した。多変量解析にて、病理組織学的Grade、stained-p53、high-ERβが独立した進行リスク因子となっていた。high-ERβはリンパ節転移・術後再発の発生において、感度および陰性的中率が100%であった。Double positive(stained-p53かつhigh-ERβ)症例は、他の群に比べ、有意にDisease-free-survivalが短いという結果であった。子宮内膜癌においてp53、ERβが癌進行リスクの予測因子になりうると同時に癌幹細胞が深く関与している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We examined the immunohistochemical expression profiles of p53 and estrogen receptor (ER) β proteins in patients with endometrial endometrioid carcinoma who underwent surgical treatment at our hospital (n = 154). By multivariate analysis, we found that histological grades, detection of immunoreactive p53 and high expression of ERβ (high-ERβ) were independently associated with metastasis and/or recurrence. Among these parameters, the sensitivity and negative predictive values of high-ERβ were very high (up to 100%). The disease- free survival of patients who were double-positive for p53-stained and high-ERβ was significantly shorter than that in other patients. These results suggess that double-positivity for p53-stained and high-ERβ may provide a promising clinical indicator to predict the risk of progression in endomterial cancer. Furthermore, p53 and ERβ expression may be associated with cancer stem cells (CSCs), especially CD133 and CD117 CSC markers.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K10708, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「末梢血中における子宮内膜癌幹細胞の検出とその臨床的意義の検討」課題番号15K10708\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10708/15K10708seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院産科婦人科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051599","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50377397"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50377397","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10708/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10708/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10708/15K10708seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10708/15K10708seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-18"}],"displaytype":"detail","filename":"HO-PR-NAKAMURA-M-kaken 2018-5p.pdf","filesize":[{"value":"165.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NAKAMURA-M-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45262/files/HO-PR-NAKAMURA-M-kaken 2018-5p.pdf"},"version_id":"1c1c60eb-b2c3-47d0-a5d4-ffe9dc69bd22"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"末梢血中における子宮内膜癌幹細胞の検出とその臨床的意義の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"末梢血中における子宮内膜癌幹細胞の検出とその臨床的意義の検討"},{"subitem_title":"Analysis of circulating cancer stem cells in endometrial cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-18"},"publish_date":"2019-04-18","publish_status":"0","recid":"45262","relation_version_is_last":true,"title":["末梢血中における子宮内膜癌幹細胞の検出とその臨床的意義の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:00:35.522848+00:00"}