{"created":"2023-07-27T06:51:43.783971+00:00","id":45264,"links":{},"metadata":{"_buckets":{"deposit":"8c012485-269b-4363-80b1-560e24240d28"},"_deposit":{"created_by":18,"id":"45264","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45264"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045264","sets":["2812:2813:2822"]},"author_link":["1721","24303"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮内膜癌においてCD133陽性細胞は自己増殖、分化そして造腫瘍能を有しており癌幹細胞マーカーであることを明らかにした。またCD133は臨床病理学的に予後不良因子であった。また子宮内膜癌幹細胞を分子生物学的に解析した結果、抗癌剤に抵抗性を示す遺伝子及び浸潤、転移に関与する遺伝子の発現が亢進しており悪性度の高い細胞集団であることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In endometrial cancer cells, CD133-positive cells had properties of self-renewal, tumorigenesis and differentiation, suggesting that CD133 was a potential cancer stem cell(CSC) marker. Immunohistological analysis showed that CD133 expression was significantly associated with overall survival and the independent predictive factor of survival. Furthermore, endometrial CSCs demonstrated high expression of genes associated with multi-drug resistance, invasion and metastasis, indicating that endometrial CSCs are aggressive malignant cancer cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22791521, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「子宮内膜癌幹細胞の同定と難治性癌治療法開発への応用」課題番号22791521\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791521/22791521seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院産科婦人科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051601","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50377397"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50377397","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791521/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791521/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791521/22791521seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22791521/22791521seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-NAKAMURA-M-kaken 2012-4p.pdf","filesize":[{"value":"188.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-NAKAMURA-M-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45264/files/HO-PR-NAKAMURA-M-kaken 2012-4p.pdf"},"version_id":"daa33ca6-0024-4c44-b023-fb838dc8b1ff"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"子宮内膜癌幹細胞の同定と難治性癌治療法開発への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮内膜癌幹細胞の同定と難治性癌治療法開発への応用"},{"subitem_title":"Identification of cancer stem cells and establishment of new target therapy in endometrial cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45264","relation_version_is_last":true,"title":["子宮内膜癌幹細胞の同定と難治性癌治療法開発への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:40.539707+00:00"}