{"created":"2023-07-27T06:51:43.872516+00:00","id":45266,"links":{},"metadata":{"_buckets":{"deposit":"53cbb81c-a22a-45f1-aacb-1139c0738b1a"},"_deposit":{"created_by":18,"id":"45266","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45266"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045266","sets":["2812:2813:2819"]},"author_link":["24302","2736"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮内膜癌細胞の周囲に存在し、癌の生存、増殖を支持しているとされる癌線維芽細胞をターゲットとした治療戦略を確立すべく基礎的研究を行った。臨床検体の検討で癌線維芽細胞において発現低下のみられる分泌型タンパクIGFBP6に着目した。\n細胞株を用いた実験にて子宮内膜癌細胞は増殖因子IGF-2依存性増殖が確認された。IGFBP6はIGF-2の抑制因子であり、その添加によってIGF-2依存性増殖がキャンセルされることを証明した。これは癌線維芽細胞におけるIGFBP6発現低下が癌生存に有利な微小環境を作っており、その発現誘導が新たながん治療ターゲットとして有効である可能性を示す結果であると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We investigeted the strategy to target cancer associated fibroblast(CAF) for endomertial cancer treatment.Analysis of clinical sample revieled decreased expression of secreatary protein,IGFBP6,in CAF. In vitro assay using cell lines also revieled IGF-2 dependent growth of endometrial cancer is canceled by addition of IGFBP6. This result suggest the possibility of inducing IGFBP6 in CAF as a new strategy to treat endometrial cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24592507, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「癌間質線維芽細胞を標的とした新たな子宮内膜癌治療戦略の開発」課題番号24592507\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592507/24592507seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院産科婦人科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051603","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00420331"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00420331","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592507/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592507/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592507/24592507seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592507/24592507seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-MIZUMOTO-Y-kaken 2015-4p.pdf","filesize":[{"value":"155.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIZUMOTO-Y-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45266/files/HO-PR-MIZUMOTO-Y-kaken 2015-4p.pdf"},"version_id":"fd87285f-4d73-406d-99bd-74c576f9825f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌間質線維芽細胞を標的とした新たな子宮内膜癌治療戦略の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌間質線維芽細胞を標的とした新たな子宮内膜癌治療戦略の開発"},{"subitem_title":"Development of new treatment strategy against endometrial cancer targeting cancer assosiated fibroblast","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45266","relation_version_is_last":true,"title":["癌間質線維芽細胞を標的とした新たな子宮内膜癌治療戦略の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:43:02.537360+00:00"}