{"created":"2023-07-27T06:51:44.005083+00:00","id":45269,"links":{},"metadata":{"_buckets":{"deposit":"f08be77a-708b-428e-8992-1a32581a9219"},"_deposit":{"created_by":18,"id":"45269","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45269"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045269","sets":["2812:2813:2816"]},"author_link":["446","24563"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NOFまたはCAFとの共培養は、低浸潤性のH357細胞および高浸潤性のSCC4細胞の遊走および浸潤を有意に亢進させた。Tks5およびMT1-MMPタンパク質の両方の発現レベルおよびTks5の発現スポットの数は、H357およびSCC4両細胞ともに、SFMとの培養と比較し、NOF-CMまたはCAF-CMとの培養によって有意に増加した。 さらに、OSCC細胞の遊走能および浸潤能は、Tks5の抑制によって減少した。\nこれらの結果は、侵略馬の形成は、OSCC細胞の移動および浸潤にとって重要な機構であり、OSCC細胞と線維芽細胞との相互作用によって調節されることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Co-culture with NOF or CAF significantly increased the migration and invasion of both the low-invasive H357 and high-invasive SCC4 cells . The expression level of both Tks5 and MT1-MMP protein and the number of expression spots of Tks5 was significantly increased by culture with NOF-CM or CAF-CM compared with culture with SFM in both H357 and SCC4 cells. Moreover, the migrating and invasive abilities of OSCC cells decreased by inhibition of Tks5.\nThese results were suggested that invadopodia formation is important mechanism for migration and invasion of OSCC cells and it is regulated by interaction between OSCC cells and fibroblast.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26463038, 研究期間(年度):2014-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「口腔扁平上皮癌の浸潤・転移におけるInvadopodiaのメカニズムの解明」課題番号26463038\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26463038/26463038seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院歯科口腔外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051606","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30444201"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30444201","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26463038/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26463038/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26463038/26463038seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26463038/26463038seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-19"}],"displaytype":"detail","filename":"HO-PR-KATO-K-kaken 2018-5p.pdf","filesize":[{"value":"237.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KATO-K-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45269/files/HO-PR-KATO-K-kaken 2018-5p.pdf"},"version_id":"2adf1040-1cce-46b6-a8cd-518d2f516926"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔扁平上皮癌の浸潤・転移におけるInvadopodiaのメカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌の浸潤・転移におけるInvadopodiaのメカニズムの解明"},{"subitem_title":"Elucidation of the mechanism of invadopodia in invasion and metastasis of oral squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-19"},"publish_date":"2019-04-19","publish_status":"0","recid":"45269","relation_version_is_last":true,"title":["口腔扁平上皮癌の浸潤・転移におけるInvadopodiaのメカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:59:10.260813+00:00"}