@techreport{oai:kanazawa-u.repo.nii.ac.jp:00045271, month = {May}, note = {MTS assayならびにWestern blotにてAMPK活性化薬剤であるAICARの口腔扁平上皮癌細胞の増殖抑制効果とアポトーシス関連蛋白の変動について検討を行った。その結果、AICARの濃度依存的、時間依存的な細胞増殖抑制効果が確認された。また、それに伴いAMPKα、Phospho-AMPKα、bax、p53の経時的な発現増加ならびにbcl-2、PCNAの経時的な発現減弱を認めた。, The suppressant effect of progression and the time-dependent change of the apoptotic related protein in oral squamous cell carcinoma cell by AICAR, as AMPK activated reagent were examined using a MTS assay and western blotting. As a result, dose-dependent and time-dependent suppressant effect of progression by AICAR was confirmed. Furthermore, time-dependent increase of AMPKα, Phospho-AMPKα, bax and p53 and time-dependent decrease of bcl-2 and PCNA were confirmed by western blotting., 出典:研究課題「口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討」課題番号20791503 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/)を加工して作成}, title = {口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討}, year = {2011} }