{"created":"2023-07-27T06:51:44.093832+00:00","id":45271,"links":{},"metadata":{"_buckets":{"deposit":"48edba75-b832-4380-a642-d91735192665"},"_deposit":{"created_by":18,"id":"45271","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45271"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045271","sets":["2812:2813:2823"]},"author_link":["446","45811"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"MTS assayならびにWestern blotにてAMPK活性化薬剤であるAICARの口腔扁平上皮癌細胞の増殖抑制効果とアポトーシス関連蛋白の変動について検討を行った。その結果、AICARの濃度依存的、時間依存的な細胞増殖抑制効果が確認された。また、それに伴いAMPKα、Phospho-AMPKα、bax、p53の経時的な発現増加ならびにbcl-2、PCNAの経時的な発現減弱を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"The suppressant effect of progression and the time-dependent change of the apoptotic related protein in oral squamous cell carcinoma cell by AICAR, as AMPK activated reagent were examined using a MTS assay and western blotting. As a result, dose-dependent and time-dependent suppressant effect of progression by AICAR was confirmed. Furthermore, time-dependent increase of AMPKα, Phospho-AMPKα, bax and p53 and time-dependent decrease of bcl-2 and PCNA were confirmed by western blotting.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討」課題番号20791503\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051608","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院歯科口腔外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30444201"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30444201","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791503/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791503/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20791503/20791503seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"HO-PR-KATO-K-kanen 2011-5p.pdf","filesize":[{"value":"214.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KATO-K-kanen 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45271/files/HO-PR-KATO-K-kanen 2011-5p.pdf"},"version_id":"8fc6e1c5-a6b2-4f69-b73f-3991f64925a0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討"},{"subitem_title":"Examination of the suppressant effect of progression, invasion and metastasis in oral squamous cell carcinoma by AMPK activated reagent","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"45271","relation_version_is_last":true,"title":["口腔扁平上皮癌に対するAMPK活性化薬剤の増殖・浸潤・転移抑制効果の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:02.265554+00:00"}