{"created":"2023-07-27T06:51:44.536304+00:00","id":45281,"links":{},"metadata":{"_buckets":{"deposit":"d03ae85f-f629-4bc6-a9d1-6d99456ca777"},"_deposit":{"created_by":18,"id":"45281","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45281"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045281","sets":["2812:2813:2820"]},"author_link":["22187","78763"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"I-131 MIBGは神経芽細胞腫に対する内照射療法の治療製剤として臨床利用されており，腫瘍細胞内へ集積して殺細胞効果を発揮する。本研究は、I-131 MIBG内照射療法の効果増強獲得を目的として、プリンアルカロイドの1種であるカフェインの殺細胞効果とI-131MIBGとの相互作用を検討した。カフェインは濃度依存性にヒト神経芽細胞腫由来細胞株SK-N-SHに対して殺細胞効果を認めた。しかし、カフェインを併用する事で投与タイミングに関わらず神経芽細胞腫に対するI-131 MIBGの摂取率は低下した。I-131 MIBGの腫瘍への集積が抑制される事から抗腫瘍効果の増強は得られにくいと予想された。","subitem_description_type":"Abstract"},{"subitem_description":"I-131 meta-iodobenzylguanidine (MIBG) has been used to treat patients with high-risk neuroblastoma. I-131 MIBG accumulate into tumor cells and has an anti-tumor effect by high-energy beta-irradiation. Caffeine is classified as purine alkaloids, and has anti-tumor effect in tumor cells by inhibition of DNA-repair. This study was performed whether I-131 MIBG interacted with caffeine for human neuroblastoma cell line SK-N-SH. Cells were treated with caffeine at concentrations as high as 40 mM, and the anti-tumor effect of caffeine was concentrate-dependent. However, uptake of I-131 MIBG into neuroblastoma cells treated by caffeine was reduced independently of the load timing. These results suggest that high-dose caffeine has anti-tumor effect, but the anti-tumor effect by combined I-131 MIBG and caffeine will not be enhanced, probably by decreasing uptake of I-131 MIBG.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24791285, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞修復阻害と腫瘍内酸素化を用いた神経芽腫内照射療法の抗腫瘍効果増強」課題番号24791285\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24791285/24791285seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051618","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院核医学診療科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60622818"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60622818","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791285/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791285/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24791285/24791285seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24791285/24791285seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"HO-PR-WAKABAYASHI-H-kaken 2014-4p.pdf","filesize":[{"value":"165.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-WAKABAYASHI-H-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45281/files/HO-PR-WAKABAYASHI-H-kaken 2014-4p.pdf"},"version_id":"1c29e1e9-7393-49ae-8de1-b1a026e5130c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞修復阻害と腫瘍内酸素化を用いた神経芽腫内照射療法の抗腫瘍効果増強","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞修復阻害と腫瘍内酸素化を用いた神経芽腫内照射療法の抗腫瘍効果増強"},{"subitem_title":"Enhancing anti-tumor effect of I-131 MIBG therapy for neuroblastoma by inhibition of cell recovery","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45281","relation_version_is_last":true,"title":["細胞修復阻害と腫瘍内酸素化を用いた神経芽腫内照射療法の抗腫瘍効果増強"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:34.495902+00:00"}