{"created":"2023-07-27T06:51:44.846304+00:00","id":45288,"links":{},"metadata":{"_buckets":{"deposit":"3a479c4c-68c6-4bc5-b459-5c00cbe6d73c"},"_deposit":{"created_by":18,"id":"45288","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45288"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045288","sets":["2812:2813:2825"]},"author_link":["73928","2198"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"眼圧は、緑内障の最も大きなリスクファクターとされており、日内変動をすることが知られている。眼圧日内変動には交感神経系の関与が指摘されていること、交感神経β受容体が房水産生に関与することから、βアドレナリン受容体遺伝子のノックアウトにより眼圧の日内変動が消失するかどうかを検討した。Β1、β2アドレナリン受容体遺伝子ダブルノックアウトマウスの眼圧には、正常マウスと同様の有意な眼圧日内変動が見られた。このことから、眼圧の日内変動はβ1、β2 アドレナリン受容体を介さずに生じているか、あるいはノックアウトにより交感神経の他の受容体が代償している可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19592009, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「時計遺伝子と眼圧の中枢性制御機構の解明」研究成果報告書　課題番号19592009\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19592009/19592009seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051625","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80179168"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80179168","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592009/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592009/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19592009/19592009seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19592009/19592009seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"ME-PR-SUGIYAMA-K-kaken 2009-5p.pdf","filesize":[{"value":"150.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SUGIYAMA-K-kaken 2009-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45288/files/ME-PR-SUGIYAMA-K-kaken 2009-5p.pdf"},"version_id":"b904c9a6-1ca6-489c-a41f-a70b0f444a1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"時計遺伝子と眼圧の中枢性制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"時計遺伝子と眼圧の中枢性制御機構の解明"},{"subitem_title":"Clock gene and intraocular pressure control by central nervous system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45288","relation_version_is_last":true,"title":["時計遺伝子と眼圧の中枢性制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:14:39.959141+00:00"}