{"created":"2023-07-27T06:51:44.934513+00:00","id":45290,"links":{},"metadata":{"_buckets":{"deposit":"178f61de-3f3c-4bfd-ad60-037b189491e5"},"_deposit":{"created_by":18,"id":"45290","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45290"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045290","sets":["2812:2813:2821"]},"author_link":["384","78773"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究計画に従い、角膜内皮移植術後患者におけるドナー接着因子に関する研究を行った。具体的には、DSAEK(Descemet stripping automated endothelial keratoplasty)とnDSAEK(non-Descemet stripping automated endothelial keratoplasty)を受けたそれぞれの患者群における臨床成績とドナーの接着状況をレトロスペクティブに統計学的に解析した。その結果、術後6カ月、1年の時点で裸眼矯正視力、眼鏡矯正視力に有意差はなく、内皮細胞密度、内皮細胞密度減少率においても統計学的な有意差は認めなかった。さらに、ドナーの接着率に関しても統計的な有意差は認めなかった。共焦点顕微鏡(In vivo laser confocal microscopy, Heidelberg Retina Tomograph II, Rostock cornea module)による生体組織解析では、DSAEK後に認められる上皮下混濁、実質の針状沈着物、ドナーレシピエント層間混濁、ドナーレシピエント層間沈着物に加えて、nDSAEK後には、巨大な高輝度ドナーレシピエント層間沈着物が認められた。この巨大高輝度沈着物は圧迫されて壊死したホスト角膜内皮細胞と推測されたが、nDSAEK後のドナーの接着や、術後矯正視力には、影響を与えないことが確認された。","subitem_description_type":"Abstract"},{"subitem_description":"According to a research project, we conducted a research to compare the clinical results after DSAEK(Descemet stripping automated endothelial keratoplasty)and nDSAEK(non-Descemet stripping automated endothelial keratoplasty). As a result, no statistical difference was observed between these two groups in terms of the visual acuity, and best corrected visual acuity, endothelial cell density. Also, no differencewas observed for donor adherence rate. In vivo laser confocal microscopy revealed that subepithelial opacity, stromal needle shaped bodies, donor recipient interface opacity and particles. Most notably, giant hyperreflective materials were observed at donor recipient interface only in nDSAEK group; these were considered to be necrotic and aggregated host endothelial cells and seemed to have no side effect to postoperative visual acuity.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22591934, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析」課題番号22591934\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591934/22591934seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051627","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20303274"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20303274","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591934/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591934/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591934/22591934seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591934/22591934seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"ME-PR-KOBAYASHI-A-kaken 2013-5p.pdf","filesize":[{"value":"403.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOBAYASHI-A-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45290/files/ME-PR-KOBAYASHI-A-kaken 2013-5p.pdf"},"version_id":"916baefd-f455-42b5-8388-1de357db0178"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析"},{"subitem_title":"Development of novel endothelial keratoplasty (nDSAEK) for bullous keratopathy and its visual function analysis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45290","relation_version_is_last":true,"title":["水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:35:10.305635+00:00"}