{"created":"2023-07-27T06:51:45.023199+00:00","id":45292,"links":{},"metadata":{"_buckets":{"deposit":"558ac4a1-79b9-443f-81c5-67bbcab6608b"},"_deposit":{"created_by":18,"id":"45292","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45292"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045292","sets":["2812:2813:2817"]},"author_link":["2343","20177"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上咽頭癌細胞C666.1から分泌されるエクソソームから、当初想定されたLMP1蛋白（EBV関連腫瘍蛋白）は検出されなかった。一方、EBERs、BART-miRNAsをはじめとするEBV関連RNAsは容易に検出された。\nそのうち、miR-BART17-5pはエクソソームを経由しない特殊な機構で分泌されることが判明し、さらに化学療法抵抗性と深く関与することが示されたたえめ、治療標的となる可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"EBV-associated oncoprotein, LMP1, was not detected in nasopaheryngeal carcinoma (NPC) cell line, C666.1,-derived exosomes. In contrast, EBV-associated RNAs, such as EBERs and BART-miRNAs, was easily detected in the exosomes.\nOne of BART-miRNAs, miR-BART17-5p, was secreted in extra-ordinally pathway, but in exsosome-independent pathway. The miRNA would be expected as novel therapeutic target of NPC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26462597, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「上咽頭癌の前転移ニッチ構築機構解明と治療用エクソソーム開発」研究成果報告書　課題番号26462597\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462597/26462597seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051629","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70377414"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70377414","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462597/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462597/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462597/26462597seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462597/26462597seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"ME-PR-WAKISAKA-N-kaken 2017-5p.pdf","filesize":[{"value":"92.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WAKISAKA-N-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45292/files/ME-PR-WAKISAKA-N-kaken 2017-5p.pdf"},"version_id":"5fb4a1e8-dd15-4328-90bd-f0142eea7e25"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上咽頭癌の前転移ニッチ構築機構解明と治療用エクソソーム開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上咽頭癌の前転移ニッチ構築機構解明と治療用エクソソーム開発"},{"subitem_title":"Elucidation of mechanism to form pre-metastatic niche in nasopharyngeal carcinoma and development of exosome for its treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45292","relation_version_is_last":true,"title":["上咽頭癌の前転移ニッチ構築機構解明と治療用エクソソーム開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:26:05.727120+00:00"}