{"created":"2023-07-27T06:51:45.155921+00:00","id":45296,"links":{},"metadata":{"_buckets":{"deposit":"fc107505-6247-4303-b13e-330684059d2b"},"_deposit":{"created_by":18,"id":"45296","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45296"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045296","sets":["2812:2813:2820"]},"author_link":["26945","2194"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脱水縮合反応を基盤としたモジュール式アフィニティーラベル化法（MoAL法）は、従来のアフィニティーラベル化法の利点を生かしつつ問題点だけを克服した優れた新規タンパク質探索技術であり、今回この技術の実用化に向けた研究を飛躍的に進展させた。本課題では、薬物の標的タンパクに特異的な効率的標識化反応条件の確立と高効率的触媒ユニットの開発、極微量のタンパク質を識別する高感度検出法の開発、未知の標的タンパクの探索実験に成功した。","subitem_description_type":"Abstract"},{"subitem_description":"A modular method for affinity labeling (MoAL method), which is based on dehydrocondensing reactions in aqueous solvents and overcomes problems of conventional affinity labeling method, has been developed. In this research project, we succeeded in construction of highly efficient catalyst units for the MoAL method, development of high sensing method for trace amount of proteins, and detection of an unknown protein for some drugs by MoAL method.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590004, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脱水縮合反応を基盤とした薬物標的タンパク質の効率的探索法の開発」課題番号23590004\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590004/23590004seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051633","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10214975"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10214975","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590004/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590004/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590004/23590004seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590004/23590004seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"PH-PR-KUNISHIMA-M-kaken 2014-5p.pdf","filesize":[{"value":"440.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KUNISHIMA-M-kaken 2014-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45296/files/PH-PR-KUNISHIMA-M-kaken 2014-5p.pdf"},"version_id":"2fc227ed-2a04-4a0f-a2ff-4045f98a168b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脱水縮合反応を基盤とした薬物標的タンパク質の効率的探索法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脱水縮合反応を基盤とした薬物標的タンパク質の効率的探索法の開発"},{"subitem_title":"Developmemt of Efficient Sensing Method for Targeting Proteins Based on Dehydrocondensing Reactions","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45296","relation_version_is_last":true,"title":["脱水縮合反応を基盤とした薬物標的タンパク質の効率的探索法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:30.693749+00:00"}