{"created":"2023-07-27T06:51:45.289015+00:00","id":45299,"links":{},"metadata":{"_buckets":{"deposit":"9cc0d2d0-6005-439b-afac-bb981035a934"},"_deposit":{"created_by":18,"id":"45299","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45299"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045299","sets":["2812:2813:2819"]},"author_link":["2865","23291"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、ほ乳類では不可能な中枢神経再生が可能な魚類を用いて、LIF（白血病阻止因子）が中枢神経再生に効果的であることを明らかにした。\nゼブラフィッシュの視神経を切断すると、網膜神経節細胞（視神経の発端となる細胞）でLIF遺伝子が3日以内に上昇する。LIFは引き続きSTAT3シグナルを活性化し、神経再生に関わるGAP-43を上昇させていることがわかった。一方、LIFを低下させた場合、STAT3の活性化とGAP-43の上昇が抑えられ、視覚機能の回復が遅れることがわかった。上記の成果により、中枢神経再生にはLIFが有効に働いていることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"This research has been aimed at investigating the beneficial effect of leukemia inhibitory factor (LIF) on zebrafish optic nerve regeneration.\nThe LIF mRNA was upregulated within 3 days after optic nerve transection followed by the activation of STAT3 at 5 days. The activation of STAT3 in turn upregulated GAP-43, which is required for nerve elongation. Meanwhile, the knockdown of LIF attenuated the STAT3 activation and GAP-43 upregulation, and delayed the functional recovery during optic nerve regeneration. These result would tell that the upregulation of LIF after optic nerve transection may have a beneficial effect on optic nerve regeneration in adult zebrafish, which in turn implies the therapeutic strategies of LIF application against central nervous system injuries.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25890007, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「視神経再生に必要なリプログラム遺伝子の新たな制御機構とそのマスター遺伝子の解明」課題番号25890007\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890007/25890007seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域附属健康増進科学センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051636","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40706983"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40706983","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25890007/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25890007/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890007/25890007seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890007/25890007seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-12"}],"displaytype":"detail","filename":"ME-PR-OGAI-K-kanen 2015-4p.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OGAI-K-kanen 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45299/files/ME-PR-OGAI-K-kanen 2015-4p.pdf"},"version_id":"d42521b5-6c14-40ab-ad1c-73e8b40a48c9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"視神経再生に必要なリプログラム遺伝子の新たな制御機構とそのマスター遺伝子の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"視神経再生に必要なリプログラム遺伝子の新たな制御機構とそのマスター遺伝子の解明"},{"subitem_title":"Investigation of the mechanisms of reprograming genes and their regulatory master gene(s) during optic nerve regeneration","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"45299","relation_version_is_last":true,"title":["視神経再生に必要なリプログラム遺伝子の新たな制御機構とそのマスター遺伝子の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:42:59.290986+00:00"}