{"created":"2023-07-27T06:51:46.441721+00:00","id":45328,"links":{},"metadata":{"_buckets":{"deposit":"66c34b86-95b3-47cd-ab13-3389f284962a"},"_deposit":{"created_by":18,"id":"45328","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45328"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045328","sets":["2812:2813:2817"]},"author_link":["78822","78821"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"検体の確保の問題、費用の問題から研究対象を変更し、特定の大腸前癌病変（鋸歯状病変）において、遺伝子メチル化の解析と、臨床病理学的因子との関連の検討を行った。結果、遺伝子メチル化の多寡と腫瘍の局在に強い関連があることを見出した。それにより、S状結腸より近位に存在する鋸歯状病変は発癌可能性が高いため、治療が望ましいことが明らかとなった。さらに、病変の背景粘膜において、部位ごとの遺伝子メチル化の差がないことを見出し、鋸歯状病変には領域がん化（field cancerization）の関与が乏しいことを確認した。","subitem_description_type":"Abstract"},{"subitem_description":"Due to the shortage of expense and clinical samples, we had to change initial research plan. Instead, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions. We then compared those results with the lesions’ clinicopathological features, especially colorectal subsites. The prevalence of lesions exhibiting frequent DNA methylation was lower in the sigmoid colon and rectum than in other bowel subsites. In addition, several cancer-associated genes showed higher methylation levels within lesions in the proximal to sigmoid colon than in the sigmoid colon and rectum. These results indicate that the methylation status of lesions with BRAF mutation is strongly associated with their location. By contrast, no difference in aberrant DNA methylation was observed in normal-appearing background colonic mucosa along the bowel subsites, which may indicate the absence of an epigenetic field defect.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25460956, 研究期間(年度):2013-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「全エクソンシークエンスによる大腸癌の染色体不安定性の原因となる新規遺伝子の同定」研究成果報告書　課題番号25460956\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460956/25460956seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院消化器内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051665","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60345626"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60345626","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460956/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460956/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460956/25460956seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460956/25460956seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-13"}],"displaytype":"detail","filename":"ME-PR-SAWADA-T-kaken 2017-4p.pdf","filesize":[{"value":"597.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAWADA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45328/files/ME-PR-SAWADA-T-kaken 2017-4p.pdf"},"version_id":"4936262b-1539-49f9-b755-1dc91cfda8fd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"全エクソンシークエンスによる大腸癌の染色体不安定性の原因となる新規遺伝子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全エクソンシークエンスによる大腸癌の染色体不安定性の原因となる新規遺伝子の同定"},{"subitem_title":"Detection of novel gene mutation causing chromosomal instability using whole exome sequencing in colorectal cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-13"},"publish_date":"2018-07-13","publish_status":"0","recid":"45328","relation_version_is_last":true,"title":["全エクソンシークエンスによる大腸癌の染色体不安定性の原因となる新規遺伝子の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:26:02.812093+00:00"}