{"created":"2023-07-27T06:51:46.973390+00:00","id":45340,"links":{},"metadata":{"_buckets":{"deposit":"1b7ce93e-579f-4fc5-9cd5-288f9b097419"},"_deposit":{"created_by":18,"id":"45340","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45340"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045340","sets":["2812:2813:2823"]},"author_link":["87","78846"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"まず、ビスホスホネートを骨への輸送担体とした^<67>Ga-DOTA conjugatedビスホスホネートを合成し、その錯体の有用性を評価した。^<67>Ga-DOTA conjugatedビスホスホネートは、精製することなく、放射化学的純度95%以上で標識でき、マウスにおける体内放射能分布を検討した結果、投与後速やかに骨への高い放射能集積を示し、他の組織からは速やかにクリアランスされ、薬剤の有用性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"DOTA-conjugated bisphosphonate was synthesized using bisphosphonate as a carrier to bone. ^<67>Ga-DOTA-conjugated bisphosphonate was prepared with a radiochemical purity of over 95% without purification. In biodistribution experiments, ^<67>Ga-DOTA-conjugated bisphosphonate accumulated in bone rapidly but were hardly observed in tissues other than bone. These results indicate that ^<67>Ga-DOTA-conjugated bisphosphonate has ideal biodistribution characteristics as bone-imaging agents.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21791174, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新規放射性薬剤を用いた包括的転移性骨腫瘍診断治療法の確立を目指した研究」課題番号21791174\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791174/21791174seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051677","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30347471"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30347471","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791174/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791174/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791174/21791174seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21791174/21791174seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-19"}],"displaytype":"detail","filename":"PH-PR-OGAWA-K-kaken 2011-4p.pdf","filesize":[{"value":"216.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-OGAWA-K-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45340/files/PH-PR-OGAWA-K-kaken 2011-4p.pdf"},"version_id":"80ed2aec-d801-49f5-ac18-5a30bc025350"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規放射性薬剤を用いた包括的転移性骨腫瘍診断治療法の確立を目指した研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規放射性薬剤を用いた包括的転移性骨腫瘍診断治療法の確立を目指した研究"},{"subitem_title":"Research of aiming at the establishment of comprehensive diagnosis and therapy of metastatic bone cancer using novel radiopharmaceuticals","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-19"},"publish_date":"2018-07-19","publish_status":"0","recid":"45340","relation_version_is_last":true,"title":["新規放射性薬剤を用いた包括的転移性骨腫瘍診断治療法の確立を目指した研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:16:58.033891+00:00"}