{"created":"2023-07-27T06:51:47.062758+00:00","id":45342,"links":{},"metadata":{"_buckets":{"deposit":"8da51df9-f2c1-47d1-b0ab-76c998c88867"},"_deposit":{"created_by":18,"id":"45342","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45342"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045342","sets":["2812:2813:2822"]},"author_link":["102","78849"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"シスプラチン型白金抗がん剤の欠点である(1)耐性がんに効かない,(2)腎毒性が高い,といった副作用は,抗がん剤をイオン形にすることにより軽減できた.シスプラチン結合DNA-タンパク質会合体の芳香環スタックをモデル化したカチオン白金錯体はプロテアソーム活性阻害を新作用機構として有していた.カチオン,アニオン両錯体ともにシスプラチンより高いin vitro活性を示し,抗がん剤への応用が期待できた.","subitem_description_type":"Abstract"},{"subitem_description":"The weak points in cisplatin type Pt(II) anticancer drugs are(1) lower activity for cisplatin resistance cancer,(2) high nephrotoxicity, however, these points were solved by the introduction of the ionic form to Pt(II) complexes. The cationic Pt(II) complexes involving aromatic ring stacking, which was shown in cisplatin coordinated DNA-HMG protein adduct, showed the proteasome inhibition as a new anticancer mechanism. Both the cationic and the anionic Pt(II) complexes exhibited the excellent anticancer effect and are considered to be possible to develop the clinical anticancer drugs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21550058, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「シスプラチン耐性に有効な白金錯体の化学特性と抗がん剤への応用」課題番号21550058\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21550058/21550058seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051679","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60143913"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60143913","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21550058/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21550058/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21550058/21550058seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21550058/21550058seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-19"}],"displaytype":"detail","filename":"PH-PR-ODANI-A-kaken 2012-5p.pdf","filesize":[{"value":"335.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ODANI-A-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45342/files/PH-PR-ODANI-A-kaken 2012-5p.pdf"},"version_id":"2c1ac332-3d29-45f9-9a76-d0c47325a9df"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"シスプラチン耐性に有効な白金錯体の化学特性と抗がん剤への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シスプラチン耐性に有効な白金錯体の化学特性と抗がん剤への応用"},{"subitem_title":"Chemical Properties of Pt(II) Complexes Effective for Cisplatin Resistance Cancer and Its Application to Anticancer Drugs","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-19"},"publish_date":"2018-07-19","publish_status":"0","recid":"45342","relation_version_is_last":true,"title":["シスプラチン耐性に有効な白金錯体の化学特性と抗がん剤への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:29.874910+00:00"}