{"created":"2023-07-27T06:51:47.239237+00:00","id":45346,"links":{},"metadata":{"_buckets":{"deposit":"bc206a36-ce1b-4332-99cf-f62094d70341"},"_deposit":{"created_by":18,"id":"45346","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45346"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045346","sets":["2812:2813:2817"]},"author_link":["78854","78855"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マラリアワクチンプラットフォームとして、補体抵抗性バキュロウイルス、樹状細胞指向性バキュロウイルス、デコイレセプター発現型バキュロウイルス、サイトカイン発現型バキュロウイルス、shRNA発現型バキュロウイルスの作製に取り組んだ。うち、補体抵抗性バキュロウイルスならびにサイトカイン発現型バキュロウイルスにおいては当初の目的通りの機能を有することが確認された。これらをマウスに免疫した場合、血中に高いマラリア抗原特異的抗体が確認され、遺伝子組み換えマラリア原虫のチャレンジ感染に対し高い感染防御効果が確認された。","subitem_description_type":"Abstract"},{"subitem_description":"We have developed the malaria-vaccine platform using several kinds of modified baculovirus such as complement resistant baculovirus, dendritic targeting baculovirus, decoy-receptor expressing baculovirus, cytokine expressing baculovirus and shRNA expressing baculovirus. Among them, complement resistant baculovirus and cytokine expressing baculovirus worked very well in functional analyses. When immunized in mice, these baculovirus induced strong anti-malaria antibody response and conferred high protective efficacy against the infection with transgenic rodent malaria.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26860278, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「免疫応答を制御するバキュロウイルスを用いたマラリアワクチンプラットフォームの開発」研究成果報告書　課題番号26860278\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860278/26860278seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051683","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20608351"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20608351","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860278/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860278/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860278/26860278seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860278/26860278seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-19"}],"displaytype":"detail","filename":"PH-PR-IYORI-M-kaken 2017-5p.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-IYORI-M-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45346/files/PH-PR-IYORI-M-kaken 2017-5p.pdf"},"version_id":"f5120355-8a5d-4077-b2e9-8c004bf03d58"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫応答を制御するバキュロウイルスを用いたマラリアワクチンプラットフォームの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫応答を制御するバキュロウイルスを用いたマラリアワクチンプラットフォームの開発"},{"subitem_title":"The development of malaria vaccine platform using baculovirus regulating immune responses","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-19"},"publish_date":"2018-07-19","publish_status":"0","recid":"45346","relation_version_is_last":true,"title":["免疫応答を制御するバキュロウイルスを用いたマラリアワクチンプラットフォームの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:25:58.675043+00:00"}