{"created":"2023-07-27T06:51:47.460786+00:00","id":45352,"links":{},"metadata":{"_buckets":{"deposit":"1fcf42b8-b757-431f-9006-bdae1b7fcf8c"},"_deposit":{"created_by":18,"id":"45352","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45352"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045352","sets":["2812:2813:2821"]},"author_link":["78856","78857"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ハマダラカ唾液腺特異的プロモーターを用いて、唾液腺にワクチン抗原を発現させることに成功した。作製した遺伝子組換え蚊(TG)の口吻から組換えタンパクが放出される様子観察することに成功した。また、抗マラリア抗体を唾液成分として発現するTGを作製し、この蚊はマラリア原虫の伝播能が著しく阻害されることを証明した。","subitem_description_type":"Abstract"},{"subitem_description":"We have successfully expressed vaccine antigens in the salivary glands of anopheline mosquitoes using the salivary gland-specific promoter. We observed that the transgenic mosquitoes released saliva containing the vaccine antigen through their proboscis. We made another transgenic mosquito expressing anti-malaria antibody in the salivary glands. The transgenic mosquito strongly impaired malaria transmission from mosquito to host.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21390126, 研究期間(年度):2009-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「トランスジェニック蚊を用いたマラリア原虫-唾液腺の相互作用の解明」課題番号21390126\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390126/21390126seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051689","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10296121"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10296121","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390126/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390126/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390126/21390126seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390126/21390126seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-19"}],"displaytype":"detail","filename":"PH-PR-YOSHIDA-S-kaken 2013-5p.pdf","filesize":[{"value":"367.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YOSHIDA-S-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45352/files/PH-PR-YOSHIDA-S-kaken 2013-5p.pdf"},"version_id":"362a4a82-c380-4825-8117-f68ab208442e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"トランスジェニック蚊を用いたマラリア原虫-唾液腺の相互作用の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トランスジェニック蚊を用いたマラリア原虫-唾液腺の相互作用の解明"},{"subitem_title":"Elucidation of interaction between malaria parasites and salivary glands using transgenic mosquitoes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-19"},"publish_date":"2018-07-19","publish_status":"0","recid":"45352","relation_version_is_last":true,"title":["トランスジェニック蚊を用いたマラリア原虫-唾液腺の相互作用の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:35:05.508373+00:00"}