{"created":"2023-07-27T06:51:47.901300+00:00","id":45362,"links":{},"metadata":{"_buckets":{"deposit":"473aa32a-4642-458a-96b0-45584429cf49"},"_deposit":{"created_by":18,"id":"45362","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45362"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045362","sets":["2812:2813:2816"]},"author_link":["580","78873"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2016-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝消失型薬物の一部は、血漿中からの消失が慢性腎障害時に遅延する。そこで、OATP1B1阻害作用を有する生体内化合物を探索したところ、6-OH indoleはOATP1B1を阻害した。血漿中6-OH indole濃度は、腎障害患者において、正常腎機能患者よりも血漿中濃度が高かった。この化合物によるOATP1B1阻害作用は持続的であり、プレインキュベーション時のみに添加した際にも阻害作用を有した。さらに、本化合物は、ヒト初代培養肝細胞でestrone 3-sulfateの細胞内取り込みを阻害した。本化合物は、慢性腎障害時に血液中に蓄積してOATP1B1の機能阻害を引き起こすことが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Several uremic tocxins have been proposed to inhibit hepatic uptake transporters. The purpose of this study is to find possible inhibition of OATP1B1 by newly identified uremic toxins, 6-OH indole. 6-OH indole inhibited OATP1B1-mediated uptake of [3H]estrone sulfate in HEK293/OATP1B1 cells. Plasma concentration of 6-OH indole was higher in patients with severe renal failure than that in patients without renal failure. The inhibition pattern of OATP1B1 by 6-OH indole was long-lasting, since its inhibition was maintained after 6-OH indole was washed out. Also, 6-OH indole inhibited uptake of estrone sulfate in primary cultured hepatocytes without changing mRNA expression of OATP1B1. These results suggest that increase of 6-OH indole in plasma during CKD could at least partially explain the delayed elimination of OATP1B1 substrate drugs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K18934, 研究期間(年度):2016-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発」課題番号16K18934\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051699","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90708140"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90708140","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-19"}],"displaytype":"detail","filename":"PH-PR-MASUO-Y-kaken 2018-5p.pdf","filesize":[{"value":"169.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MASUO-Y-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45362/files/PH-PR-MASUO-Y-kaken 2018-5p.pdf"},"version_id":"d7f523dc-a687-43c7-9d4f-057968b75f31"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発"},{"subitem_title":"Developments in estimation of the functional changes of transporters and drug metabolizing enzymes during renal failure","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-19"},"publish_date":"2019-04-19","publish_status":"0","recid":"45362","relation_version_is_last":true,"title":["慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:58:53.459073+00:00"}