{"created":"2023-07-27T06:51:47.989757+00:00","id":45365,"links":{},"metadata":{"_buckets":{"deposit":"6ded8d9c-8729-4307-9736-3f819ede926e"},"_deposit":{"created_by":18,"id":"45365","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45365"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045365","sets":["2812:2813:2818"]},"author_link":["78875","248"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症の大脳皮質におけるパルブアルブミン（PV）陽性ニューロンの変化とGABA-A受容体α1サブユニット（GABA-Aα1）の発現低下の因果関係を明らかにするために、それぞれの変化を再現した遺伝子操作マウスの大脳皮質を解析した。GABA-Aα1ノックアウトマウスでは、GABA合成酵素GAD67やPVの発現に変化は認められなかった。PVニューロン特異的GAD67ノックアウトマウスでも、GABA-Aα1の発現に有意な変化は認められなかった。統合失調症におけるPVニューロンの変化とGABA-Aα1の発現低下の間の因果関係は支持されず、両者は他の上流メカニズムにより生じていると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"In schizophrenia, alterations in the subset of cortical inhibitory neurons that express parvalbumin (PV) have been indicated by reduced expression of PV and GAD67, an enzyme for GABA synthesis, in these neurons. These alterations were accompanied by reduced expression of GABA-A receptor α1 (GABA-Aα1) subunit that mediates inhibitory neurotransmission by PV neurons. We tested a causal relationship between the changes in PV neurons and GABA-Aα1 expression through analyzing cortical gene expression in genetically engineered mice. In GABA-Aα1 knockout mice, we did not detect a significant change in GAD67 or PV mRNAs. Conversely, in mice with a conditional knockout of GAD67 in PV neurons, GABA-Aα1 mRNA expression was unaltered. These results did not support a relationship between the changes in PV neurons and GABA-Aα1 expression in the cortex of subjects with schizophrenia. There might be a common upstream mechanism that drives both changes in cortical inhibition in schizophrenia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26670536, 研究期間(年度):2014-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「統合失調症の大脳皮質抑制性介在ニューロン変化におけるGABA受容体遺伝子の役割」課題番号26670536\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670536/26670536seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051702","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40249959"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40249959","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670536/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670536/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670536/26670536seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670536/26670536seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-HASHIMOTO-T-kaken 2016-4p.pdf","filesize":[{"value":"217.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HASHIMOTO-T-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45365/files/ME-PR-HASHIMOTO-T-kaken 2016-4p.pdf"},"version_id":"8e43358f-2962-4b8b-8da0-ba3a7dfd9ffe"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合失調症の大脳皮質抑制性介在ニューロン変化におけるGABA受容体遺伝子の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症の大脳皮質抑制性介在ニューロン変化におけるGABA受容体遺伝子の役割"},{"subitem_title":"Relationship between altered PV neuron function and reduced GABA-A receptor alpha1 subunit expression in the cortex of subjects with schizophrenia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45365","relation_version_is_last":true,"title":["統合失調症の大脳皮質抑制性介在ニューロン変化におけるGABA受容体遺伝子の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:14.153122+00:00"}