{"created":"2023-07-27T06:51:48.077513+00:00","id":45367,"links":{},"metadata":{"_buckets":{"deposit":"94f49a59-ae4a-420e-ac7e-78d8aac48627"},"_deposit":{"created_by":18,"id":"45367","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45367"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045367","sets":["2812:2813:2820"]},"author_link":["78875","248"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"78875","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40249959","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40249959"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"統合失調症の症状出現に関わる神経回路を解明するため、黒質網状層の抑制性ニューロンと、それにより抑制される黒質緻密層のドーパミンニューロンで、統合失調症での遺伝子発現の変化を、14対の性別と年齢がマッチした健常例および統合失調症例から得られた脳切片を用いて調べた。網状層では、抑制性伝達物質GABAの合成酵素であるGAD67のmRNA発現には有意な変化は認めなかった。緻密層では、ドーパミン合成を行うチロシン水酸化酵素およびKNCS3カリウムチャネルサブユニットのmRNA発現が有意に低下していた。膜興奮性を抑制するKCNS3の発現低下がドーパミンの放出過剰と陽性症状に関与する可能性が考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We tested our hypothesis that GABA neurotransmission by projection neurons in the substantia nigra pars reticulata (SNR) is reduced and dopamine neurons in the substantia nigra pars compacta (SNC) are hyperactive as the result. We analyzed gene expression for GAD67, an enzyme for GABA synthesis, tyrosine hydroxylase (TH), an enzyme for dopamine synthesis, and KCNS3 voltage-gated potassium channel subunit in the SNR and SNC of 14 pairs of control and sex- and age-matched schizophrenia subjects, using in situ hybridization. In the SNR, GAD67 mRNA levels did not differ between control and schizophrenia subjects. In contrast, TH and KCNS3 mRNA levels were significantly lower in the SNC of schizophrenia subjects. Our results did not support altered GABA neurotransmission by SNR neurons. However, decreased KCNS3 expression could enhance excitability of SNC dopamine neurons, contributing to positive symptoms. Lower TH levels might reflect a compensatory mechanism.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24659539, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「統合失調症における大脳基底核出力ニューロンの死後脳を用いた解析」課題番号24659539\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659539/24659539seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051704","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40249959"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40249959","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659539/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659539/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659539/24659539seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659539/24659539seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋本, 隆紀"}],"nameIdentifiers":[{"nameIdentifier":"248","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40249959","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40249959"},{"nameIdentifier":"40249959","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40249959"},{"nameIdentifier":"40249959","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040249959"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-HASHIMOTO-T-kaken 2014-4p.pdf","filesize":[{"value":"211.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HASHIMOTO-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45367/files/ME-PR-HASHIMOTO-T-kaken 2014-4p.pdf"},"version_id":"187140e2-f2c0-413b-bb0c-a40ca1ea3b26"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合失調症における大脳基底核出力ニューロンの死後脳を用いた解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症における大脳基底核出力ニューロンの死後脳を用いた解析"},{"subitem_title":"Gene Exression in the Substantina Nigra of Subjects with Schizophrenia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45367","relation_version_is_last":true,"title":["統合失調症における大脳基底核出力ニューロンの死後脳を用いた解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:49:37.813572+00:00"}